(Q52553687)

3 May 2018

title

Structure-based design of a potent chimeric thrombin inhibitor. (English)

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3 May 2018

5

Stürzebecher J

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3 May 2018

author name string

Morenweiser R

1

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3 May 2018

Auerswald EA

2

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van de Locht A

3

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Fritz H

4

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Stubbs MT

6

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3 May 2018

language of work or name

English

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publication date

1 August 1997

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3 May 2018

Journal of Biological Chemistry

published in

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volume

272

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issue

32

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3 May 2018

page(s)

19938-19942

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3 May 2018

The clot thickens: clues provided by thrombin structure.

cites work

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Binding of the bovine basic pancreatic trypsin inhibitor (Kunitz) to human alpha-, beta- and gamma-thrombin; a kinetic and thermodynamic study

21 January 2018

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The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

21 January 2018

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The structure of a complex of recombinant hirudin and human alpha-thrombin

21 January 2018

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Natural protein proteinase inhibitors and their interaction with proteinases

21 January 2018

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A Kazal-type inhibitor of human mast cell tryptase: isolation from the medical leech Hirudo medicinalis, characterization, and sequence analysis.

21 January 2018

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The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition

21 January 2018

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A player of many parts: the spotlight falls on thrombin's structure.

21 January 2018

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The interaction of thrombin with fibrinogen. A structural basis for its specificity

21 January 2018

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Improved methods for building protein models in electron density maps and the location of errors in these models

21 January 2018

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Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

21 January 2018

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The specific velocity plot. A graphical method for determining inhibition parameters for both linear and hyperbolic enzyme inhibitors.

21 January 2018

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Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site

21 January 2018

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A new member of the plasma protease inhibitor gene family

21 January 2018

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Glu-192----Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin

21 January 2018

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The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin

21 January 2018

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

21 January 2018

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SETOR: hardware-lighted three-dimensional solid model representations of macromolecules

21 January 2018

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Structure of leech derived tryptase inhibitor (LDTI-C) in solution

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.272.32.19938

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3 May 2018

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3 May 2018