(Q52564198)

3 May 2018

title

Clinical applicability of current pharmacokinetic models: splanchnic elimination of 5-fluorouracil in cancer patients. (English)

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3 May 2018

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4

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author name string

P J Robinson

1

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3 May 2018

L Bass

2

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S M Pond

3

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J G Wagner

5

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publication date

1 June 1988

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3 May 2018

Journal of Pharmacokinetics and Pharmacodynamics

published in

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3 May 2018

volume

16

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issue

3

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3 May 2018

page(s)

229-249

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3 May 2018

https://scigraph.springernature.com/pub.10.1007/bf01062135

exact match

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cites work

Clearance concepts in pharmacokinetics

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Hepatic elimination of flowing substrates: the distributed model

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Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparation

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF01062135

Effects of capillary heterogeneity on rates of steady uptake of substances by the intact liver

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF01062135

A mathematical model of the kinetics of 5-fluorouracil and its catabolites in freshly isolated rat hepatocytes.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF01062135

Flow dependence of first-order uptake of substances by heterogeneous perfused organs

21 January 2018

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12 December 2020

Pulmonary elimination of 5-fluorouracil in anesthetized rats.

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The disposition of propranolol. 8. General implications of the effects of liver blood flow on elimination from the perfused rat liver

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A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations.

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Factors affecting drug metabolism

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The physiological disposition of 5-fluorouracil in mice bearing solid L1210 lymphocytic leukemia.

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Michaelis-Menten kinetics of galactose elimination by the isolated perfused pig liver

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Effect of sinusoidal perfusion on galactose elimination kinetics in perfused rat liver

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Regional and systemic serum concentrations of 5-fluorouracil after portal and intravenous infusion: an experimental study in dogs

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12 December 2020

How small is the functional variability of liver sinusoids?

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12 December 2020

The effect of hepatic blood flow on taurocholate extraction by the isolated perfused rat liver

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12 December 2020

Flow dependence of propranolol elimination in perfused rat liver

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Circulatory pathways in the rat liver as revealed by P32 chromic phosphate colloid uptake in the isolated perfused liver preparation

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Portal levels and hepatic clearance of 5-fluorouracil after intraperitoneal administration in humans

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Enzymatic elimination of substrates flowing through the intact liver

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On the relation between extended forms of the sinusoidal perfusion and of the convection-dispersion models of hepatic elimination

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Steady-state nonlinear pharmacokinetics of 5-fluorouracil during hepatic arterial and intravenous infusions in cancer patients.

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12 December 2020

Saturation kinetics in hepatic drug removal: a statistical approach to functional heterogeneity

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Identifiers

DOI

10.1007/BF01062135

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3 May 2018

PubMed ID

3221324

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3 May 2018