(Q52571625)

3 May 2018

title

Role of the activation loop tyrosines in regulation of the insulin-like growth factor I receptor-tyrosine kinase. (English)

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3 May 2018

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Wanqing Li

1

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3 May 2018

W Todd Miller

series ordinal

2

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3 May 2018

language of work or name

English

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publication date

22 June 2006

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3 May 2018

Journal of Biological Chemistry

published in

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3 May 2018

volume

281

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3 May 2018

issue

33

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3 May 2018

page(s)

23785-23791

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3 May 2018

Structure and function of the type 1 insulin-like growth factor receptor.

cites work

1 reference

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Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology

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The insulin-like growth factor system and cancer

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IGF-I receptor signalling in transformation and differentiation

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The IGF-I receptor in cancer research

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Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors

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In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase

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Protein tyrosine kinase structure and function

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Molecular and cellular aspects of the insulin-like growth factor I receptor

21 January 2018

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Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

21 January 2018

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Crystal structure of the tyrosine kinase domain of the human insulin receptor

21 January 2018

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Structure and autoregulation of the insulin-like growth factor 1 receptor kinase

21 January 2018

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Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity

21 January 2018

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The role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation, and tumorigenesis

21 January 2018

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Inhibition of insulin-like growth factor I receptor autophosphorylation by novel 6-5 ring-fused compounds

21 January 2018

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Conformational changes in the activation loop of the insulin receptor's kinase domain

21 January 2018

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Protein kinase inhibitors: insights into drug design from structure.

21 January 2018

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Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

21 January 2018

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The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M605269200

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3 May 2018

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3 May 2018