(Q52579752)

English

Aromatic residues and neighboring Arg414 in the (6R)-5,6,7, 8-tetrahydro-L-biopterin binding site of full-length neuronal nitric-oxide synthase are crucial in catalysis and heme reduction with NADPH.

scientific article published in August 2000

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10846172%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

Aromatic residues and neighboring Arg414 in the (6R)-5,6,7, 8-tetrahydro-L-biopterin binding site of full-length neuronal nitric-oxide synthase are crucial in catalysis and heme reduction with NADPH (English)

1 reference

Europe PubMed Central

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7 November 2019

4

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7 November 2019

author name string

Sagami I

1

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7 November 2019

Sato Y

2

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7 November 2019

Daff S

3

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7 November 2019

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1 August 2000

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7 November 2019

Journal of Biological Chemistry

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7 November 2019

275

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7 November 2019

34

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7 November 2019

26150-26157

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7 November 2019

Nitric oxide synthases: properties and catalytic mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Structure-function aspects in the nitric oxide synthases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Nitric oxide synthases: why so complex?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Characterization of heme-deficient neuronal nitric-oxide synthase reveals a role for heme in subunit dimerization and binding of the amino acid substrate and tetrahydrobiopterin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Subunit interactions of endothelial nitric-oxide synthase. Comparisons to the neuronal and inducible nitric-oxide synthase isoforms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Inducible nitric oxide synthase: identification of amino acid residues essential for dimerization and binding of tetrahydrobiopterin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Endothelial nitric-oxide synthase. Expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Tetrahydrobiopterin binding to macrophage inducible nitric oxide synthase: heme spin shift and dimer stabilization by the potent pterin antagonist 4-amino-tetrahydrobiopterin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Anti-pterins as tools to characterize the function of tetrahydrobiopterin in NO synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Reactivity of tetrahydrobiopterin bound to nitric-oxide synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Activation of neuronal nitric-oxide synthase by the 5-methyl analog of tetrahydrobiopterin. Functional evidence against reductive oxygen activation by the pterin cofactor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Reaction of neuronal nitric-oxide synthase with oxygen at low temperature. Evidence for reductive activation of the oxy-ferrous complex by tetrahydrobiopterin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Structure of nitric oxide synthase oxygenase dimer with pterin and substrate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Mutational analysis of the tetrahydrobiopterin-binding site in inducible nitric-oxide synthase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

High-level expression of functional rat neuronal nitric oxide synthase in Escherichia coli

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Prokaryotic expression of the heme- and flavin-binding domains of rat neuronal nitric oxide synthase as distinct polypeptides: identification of the heme-binding proximal thiolate ligand as cysteine-415.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

The crucial roles of Asp-314 and Thr-315 in the catalytic activation of molecular oxygen by neuronal nitric-oxide synthase. A site-directed mutagenesis study.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Molecular cloning and characterization of human endothelial nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Cloning and characterization of inducible nitric oxide synthase from mouse macrophages

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Molecular and biochemical characterization of dNOS: a Drosophila Ca2+/calmodulin-dependent nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Effects of pH on the structure and function of neuronal nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Domain swapping in inducible nitric-oxide synthase. Electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Formation of a Pterin Radical in the Reaction of the Heme Domain of Inducible Nitric Oxide Synthase with Oxygen†

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Comparative functioning of dihydro- and tetrahydropterins in supporting electron transfer, catalysis, and subunit dimerization in inducible nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Reactions catalyzed by tetrahydrobiopterin-free nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Nitric oxide-generated P420 nitric oxide synthase: characterization and roles for tetrahydrobiopterin and substrate in protecting against or reversing the P420 conversion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Tetrahydrobiopterin inhibits monomerization and is consumed during catalysis in neuronal NO synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Crucial role of Lys(423) in the electron transfer of neuronal nitric-oxide synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

The 42-amino acid insert in the FMN domain of neuronal nitric-oxide synthase exerts control over Ca(2+)/calmodulin-dependent electron transfer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Subunit dissociation and unfolding of macrophage NO synthase: relationship between enzyme structure, prosthetic group binding, and catalytic function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Tetrahydrobiopterin-Free Neuronal Nitric Oxide Synthase: Evidence for Two Identical Highly Anticooperative Pteridine Binding Sites†

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Tetrahydrobiopterin-dependent inhibition of superoxide generation from neuronal nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M000534200

21 January 2018

Identifiers

10.1074/JBC.M000534200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10846172%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10846172%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

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