(Q52617694)

4 May 2018

title

BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1. (English)

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4 May 2018

author name string

Lisa Dohrn

1

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4 May 2018

Daniela Salles

2

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4 May 2018

Simone Y Siehler

3

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4 May 2018

Julia Kaufmann

4

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4 May 2018

Lisa Wiesmüller

5

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4 May 2018

language of work or name

English

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publication date

1 February 2012

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4 May 2018

published in

Biochemical Journal

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4 May 2018

volume

441

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4 May 2018

issue

3

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4 May 2018

page(s)

919-926

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4 May 2018

Welcome the family of FANCJ-like helicases to the block of genome stability maintenance proteins

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Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene

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BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function

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The BRCT Domain Is a Phospho-Protein Binding Domain

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The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations

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BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ.

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The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair

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Targeting the FANCJ-BRCA1 interaction promotes a switch from recombination to poleta-dependent bypass

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FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange

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Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2

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The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells

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Human MutL-complexes monitor homologous recombination independently of mismatch repair

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Direct DNA binding by Brca1

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A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining.

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DNA substrate dependence of p53-mediated regulation of double-strand break repair

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NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes

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Poly(ADP-RIBOSE) polymerase-1 (Parp-1) antagonizes topoisomerase I-dependent recombination stimulation by P53

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CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

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Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2.

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Brca1 controls homology-directed DNA repair

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A sensitive test for the detection of specific DSB repair defects in primary cells from breast cancer specimens

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BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control

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Signalling cell cycle arrest and cell death through the MMR System

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Exonuclease function of human Mre11 promotes deletional nonhomologous end joining

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Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

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Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome

21 January 2018

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Activation of BRCA1/BRCA2-associated helicase BACH1 is required for timely progression through S phase

21 January 2018

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Functional characterization connects individual patient mutations in ataxia telangiectasia mutated (ATM) with dysfunction of specific DNA double-strand break-repair signaling pathways

21 January 2018

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Breast cancer risk and the DNA double-strand break end-joining capacity of nonhomologous end-joining genes are affected by BRCA1.

21 January 2018

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The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression

21 January 2018

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Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

21 January 2018

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CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle.

21 January 2018

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Requirement for the SRS2 DNA helicase gene in non-homologous end joining in yeast

21 January 2018

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Nej1 recruits the Srs2 helicase to DNA double-strand breaks and supports repair by a single-strand annealing-like mechanism.

21 January 2018

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FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein

21 January 2018

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Replication protein A is required for etoposide-induced assembly of MRE11/RAD50/NBS1 complex repair foci.

21 January 2018

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The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability

21 January 2018

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Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1042/BJ20110314

1 reference

4 May 2018

1 reference

4 May 2018