(Q52639534)

5 May 2018

title

A dispersion model of hepatic elimination: 3. Application to metabolite formation and elimination kinetics. (English)

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5 May 2018

author

Michael S. Roberts

series ordinal

1

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5 May 2018

author name string

M Rowland

series ordinal

2

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5 May 2018

publication date

1 June 1986

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5 May 2018

Journal of Pharmacokinetics and Pharmacodynamics

published in

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5 May 2018

volume

14

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5 May 2018

issue

3

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5 May 2018

page(s)

289-308

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5 May 2018

https://scigraph.springernature.com/pub.10.1007/bf01106708

exact match

0 references

cites work

Clearance concepts in pharmacokinetics

1 reference

https://api.crossref.org/works/10.1007%2FBF01106708

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01106708

21 January 2018

Continuous flow systems

1 reference

https://api.crossref.org/works/10.1007%2FBF01106708

Curve fitting and modeling in pharmacokinetics and some practical experiences with NONLIN and a new program FUNFIT

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01106708

Hepatic clearance of drugs. III. Additional experimental evidence supporting the "well-stirred" model, using metabolite (MEGX) generated from lidocaine under varying hepatic blood flow rates and linear conditions in the perfused rat liver in situ pr

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01106708

A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations.

21 January 2018

1 reference

12 December 2020

Functional implications of liver cell heterogeneity.

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12 December 2020

A dispersion model of hepatic elimination: 2. Steady-state considerations-influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity

1 reference

12 December 2020

Quantitative morphology of the sinusoids of the hepatic acinus. Quantimet analysis of rat liver

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12 December 2020

Kinetics of metabolite formation and elimination in the perfused rat liver preparation: differences between the elimination of preformed acetaminophen and acetaminophen formed from phenacetin

1 reference

12 December 2020

Retrograde perfusion to probe the heterogeneous distribution of hepatic drug metabolizing enzymes in rats

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12 December 2020

A linear method for determining liver sinusoidal and extravascular volumes

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12 December 2020

On the location of cellular functions in perfused organs

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12 December 2020

The terminal hepatic microcirculation in the rat

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12 December 2020

Liver blood flow. II. Effects of drugs and hormones on liver blood flow

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Functional zones in rat liver: The degree of overlap

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12 December 2020

Identifiers

DOI

10.1007/BF01106708

1 reference

5 May 2018

1 reference

5 May 2018