(Q52681588)

English

Alterations in DNA Damage Response and Repair Genes as Potential Marker of Clinical Benefit From PD-1/PD-L1 Blockade in Advanced Urothelial Cancers.

scientific article published on 28 February 2018

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

Alterations in DNA Damage Response and Repair Genes as Potential Marker of Clinical Benefit From PD-1/PD-L1 Blockade in Advanced Urothelial Cancers. (English)

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

object named as

Kenneth Seier

2

0 references

object named as

Min Yuen Teo

1

0 references

Jedd D. Wolchok

16

object named as

Jedd D Wolchok

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

Irina Ostrovnaya

3

object named as

Irina Ostrovnaya

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

author name string

Ashley M Regazzi

4

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

Brooke E Kania

5

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

Meredith M Moran

6

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

Catharine K Cipolla

7

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

Mark J Bluth

8

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

Joshua Chaim

9

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

Hikmat Al-Ahmadie

10

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

Alexandra Snyder

11

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

Maria I Carlo

12

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

David B Solit

13

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

Michael F Berger

14

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

Samuel Funt

15

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

Gopa Iyer

17

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

Dean F Bajorin

18

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

Margaret K Callahan

19

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

Jonathan E Rosenberg

20

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

language of work or name

0 references

publication date

28 February 2018

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

Journal of Clinical Oncology

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

36

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

17

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

1685-1694

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic factors in patients with advanced transitional cell carcinoma of the urothelial tract experiencing treatment failure with platinum-containing regimens

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secondary variants in individuals undergoing exome sequencing: screening of 572 individuals identifies high-penetrance mutations in cancer-susceptibility genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comprehensive molecular characterization of urothelial bladder carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic ERCC2 mutations correlate with cisplatin sensitivity in muscle-invasive urothelial carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Whole-exome sequencing of muscle-invasive bladder cancer identifies recurrent mutations of UNC5C and prognostic importance of DNA repair gene mutations on survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PD-1 blockade induces responses by inhibiting adaptive immune resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Self-DNA, STING-dependent signaling and the origins of autoinflammatory disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defects in DNA Repair Genes Predict Response to Neoadjuvant Cisplatin-based Chemotherapy in Muscle-invasive Bladder Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Germline Variants in Targeted Tumor Sequencing Using Matched Normal DNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical Validation of Chemotherapy Response Biomarker ERCC2 in Muscle-Invasive Urothelial Bladder Carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nivolumab monotherapy in recurrent metastatic urothelial carcinoma (CheckMate 032): a multicentre, open-label, two-stage, multi-arm, phase 1/2 trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

COSMIC: somatic cancer genetics at high-resolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cGAS is essential for the antitumor effect of immune checkpoint blockade

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA Damage Response and Repair Gene Alterations Are Associated with Improved Survival in Patients with Platinum-Treated Advanced Urothelial Carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Avelumab, an Anti-Programmed Death-Ligand 1 Antibody, In Patients With Refractory Metastatic Urothelial Carcinoma: Results From a Multicenter, Phase Ib Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA Damage and Repair Biomarkers of Immunotherapy Response

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

OncoKB: A Precision Oncology Knowledge Base

1 reference

https://pubmed.ncbi.nlm.nih.gov/29489427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1200/JCO.2017.75.7740

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

release_wpxtut62fzatnfatfimaq3l7uu

1 reference

https://api.fatcat.wiki/v0/release/wpxtut62fzatnfatfimaq3l7uu

24 November 2022

based on heuristic

mapped directly with Wikidata item

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6366295

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q52681588&oldid=1985479570"