(Q52683626)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29485043%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

title

Inhibitors of HIF-1α and CXCR4 Mitigate the Development of Radiation Necrosis in Mouse Brain (English)

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18 March 2020

1

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18 March 2020

Chong Duan

2

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18 March 2020

author name string

Liya Yuan

3

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18 March 2020

John A Engelbach

4

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18 March 2020

Christina I Tsien

5

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18 March 2020

Scott C Beeman

6

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18 March 2020

Carlos J Perez-Torres

7

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18 March 2020

Xia Ge

8

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18 March 2020

Keith M Rich

9

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18 March 2020

Joseph J H Ackerman

10

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18 March 2020

Joel R Garbow

11

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18 March 2020

language of work or name

English

0 references

publication date

21 December 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29485043%20AND%20SRC:MED&resulttype=core&format=json

International Journal of Radiation Oncology Biology Physics

18 March 2020

published in

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18 March 2020

volume

100

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18 March 2020

issue

4

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18 March 2020

page(s)

1016-1025

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Activity of topotecan, a new topoisomerase I inhibitor, against human tumor colony-forming units in vitro

18 March 2020

cites work

1 reference

12 December 2020

Radiation Sensitivity of Rodent Species

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12 December 2020

The LD50 for uniform low LET irradiation of man

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12 December 2020

Conservative treatment of delayed cerebral radiation necrosis

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12 December 2020

Treatment of radiation-induced nervous system injury with heparin and warfarin

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12 December 2020

Malignant gliomas: MR imaging spectrum of radiation therapy- and chemotherapy-induced necrosis of the brain after treatment.

1 reference

12 December 2020

Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway.

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12 December 2020

IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis

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12 December 2020

A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.

1 reference

12 December 2020

Results of contemporary surgical management of radiation necrosis using frameless stereotaxis and intraoperative magnetic resonance imaging

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12 December 2020

The significance of cancer cell expression of the chemokine receptor CXCR4.

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12 December 2020

The efficacy of hyperbaric oxygen therapy in the treatment of radiation-induced late side effects

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12 December 2020

Schedule-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts

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12 December 2020

Regulation of the chemokine receptor CXCR4 and metastasis by hypoxia-inducible factor in non small cell lung cancer cell lines

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12 December 2020

Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis

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12 December 2020

Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo

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12 December 2020

CXCR4/CXCL12 axis promotes VEGF-mediated tumor angiogenesis through Akt signaling pathway

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12 December 2020

Involvement of SDF-1alpha/CXCR4 axis in the enhanced peritoneal metastasis of epithelial ovarian carcinoma

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12 December 2020

Pathological review of late cerebral radionecrosis

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12 December 2020

Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma

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12 December 2020

Hypoxia enhances CXCR4 expression by activating HIF-1 in oral squamous cell carcinoma.

1 reference

12 December 2020

HIF-1 in the inflammatory microenvironment

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12 December 2020

Randomized double-blind placebo-controlled trial of bevacizumab therapy for radiation necrosis of the central nervous system

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12 December 2020

Hypoxia increases the metastatic ability of breast cancer cells via upregulation of CXCR4

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12 December 2020

SDF1/CXCL12 is involved in recruitment of stem-like progenitor cells to orthotopic murine malignant mesothelioma spheroids

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12 December 2020

Repeated treatments with bevacizumab for recurrent radiation necrosis in patients with malignant brain tumors: a report of 2 cases

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12 December 2020

Exacerbation of cerebral radiation necrosis by bevacizumab.

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12 December 2020

CXCL12-CXCR4 axis in angiogenesis, metastasis and stem cell mobilization.

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12 December 2020

Bevacizumab as a treatment option for radiation-induced cerebral necrosis.

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12 December 2020

Potential of CXCR4 antagonists for the treatment of metastatic lung cancer

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12 December 2020

The distribution of vascular endothelial growth factor-producing cells in clinical radiation necrosis of the brain: pathological consideration of their potential roles.

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12 December 2020

Cancer stem cells and novel targets for antitumor strategies

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12 December 2020

CXCL12 mediates trophic interactions between endothelial and tumor cells in glioblastoma

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12 December 2020

CXCR4 antagonist AMD3100 protects blood-brain barrier integrity and reduces inflammatory response after focal ischemia in mice

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12 December 2020

Phase II clinical trial of whole-brain irradiation plus three-dimensional conformal boost with concurrent topotecan for brain metastases from lung cancer

1 reference

12 December 2020

An analysis of radiation necrosis of the central nervous system treated with bevacizumab.

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12 December 2020

Hypoxia promotes migration and induces CXCR4 expression via HIF-1α activation in human osteosarcoma

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12 December 2020

Anti-VEGF antibodies mitigate the development of radiation necrosis in mouse brain

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12 December 2020

Inflammation as well as angiogenesis may participate in the pathophysiology of brain radiation necrosis

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12 December 2020

A GSK-3β inhibitor protects against radiation necrosis in mouse brain

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12 December 2020

Combined VEGF and CXCR4 antagonism targets the GBM stem cell population and synergistically improves survival in an intracranial mouse model of glioblastoma

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12 December 2020

The HIF-1α/CXCR4 pathway supports hypoxia-induced metastasis of human osteosarcoma cells

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12 December 2020

Pathophysiology, diagnosis, and treatment of radiation necrosis in the brain

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12 December 2020

The hypoxic tumor microenvironment: A driving force for breast cancer progression

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12 December 2020

Specificity of vascular endothelial growth factor treatment for radiation necrosis

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12 December 2020

A Gamma-Knife-Enabled Mouse Model of Cerebral Single-Hemisphere Delayed Radiation Necrosis

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12 December 2020

Delayed brain radiation necrosis: pathological review and new molecular targets for treatment

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12 December 2020

Metronomic topotecan impedes tumor growth of MYCN-amplified neuroblastoma cells in vitro and in vivo by therapy induced senescence

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12 December 2020

Acquired-resistance of bevacizumab treatment for radiation brain necrosis: a case report

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12 December 2020

Can anti-vascular endothelial growth factor antibody reverse radiation necrosis? A preclinical investigation.

1 reference

12 December 2020

10.1016/J.IJROBP.2017.12.257

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29485043%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29485043%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

PubMed publication ID

29485043

1 reference