(Q37866794)

24 August 2017

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title

Potential of CXCR4 antagonists for the treatment of metastatic lung cancer (English)

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24 August 2017

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Jan A Burger

1

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24 August 2017

David J Stewart

series ordinal

2

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24 August 2017

Ori Wald

series ordinal

3

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24 August 2017

Amnon Peled

series ordinal

4

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24 August 2017

publication date

1 April 2011

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Expert Review of Anticancer Therapy

24 August 2017

published in

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24 August 2017

volume

11

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24 August 2017

issue

4

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24 August 2017

page(s)

621-630

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Chemokines: a new classification system and their role in immunity

24 August 2017

cites work

1 reference

Molecular cloning and structure of a pre-B-cell growth-stimulating factor

21 January 2018

1 reference

The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

21 January 2018

1 reference

The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1

21 January 2018

1 reference

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

21 January 2018

1 reference

The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

21 January 2018

1 reference

Control of chemokine-guided cell migration by ligand sequestration

21 January 2018

1 reference

Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7

21 January 2018

1 reference

Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease

21 January 2018

1 reference

Involvement of chemokine receptors in breast cancer metastasis

21 January 2018

1 reference

Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches

21 January 2018

1 reference

In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment

21 January 2018

1 reference

Hematopoietic stem cells are uniquely selective in their migratory response to chemokines

21 January 2018

1 reference

AMD3100: CXCR4 antagonist and rapid stem cell-mobilizing agent

21 January 2018

1 reference

Enhanced unique pattern of hematopoietic cell mobilization induced by the CXCR4 antagonist 4F-benzoyl-TN14003.

21 January 2018

1 reference

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

21 January 2018

1 reference

Stem cells and their niches

21 January 2018

1 reference

Stem cells and niches: mechanisms that promote stem cell maintenance throughout life

21 January 2018

1 reference

Stem cell trafficking in tissue development, growth, and disease

21 January 2018

1 reference

The inflammatory tumor microenvironment and its impact on cancer development

21 January 2018

1 reference

Role of chemokines in tumor growth

21 January 2018

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The multifaceted roles of chemokines in malignancy

21 January 2018

1 reference

21 January 2018

1 reference

Cancer and the chemokine network

21 January 2018

1 reference

21 January 2018

Fibroblasts in cancer

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Stromal fibroblasts in cancer: a novel tumor-promoting cell type

21 January 2018

1 reference

Chemokines and the molecular basis of cancer metastasis

21 January 2018

1 reference

Molecular characterization of the tumor microenvironment in breast cancer

21 January 2018

1 reference

Distinct role of macrophages in different tumor microenvironments

21 January 2018

1 reference

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice.

21 January 2018

1 reference

CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment

21 January 2018

1 reference

Treatment outcomes by tumor histology in Eastern Cooperative Group Study E4599 of bevacizumab with paclitaxel/carboplatin for advanced non-small cell lung cancer

21 January 2018

1 reference

Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.

21 January 2018

1 reference

Differential expression of CXCR4 is associated with the metastatic potential of human non-small cell lung cancer cells.

21 January 2018

1 reference

Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome

21 January 2018

1 reference

CXCL12 and CXCR4 in adenocarcinoma of the lung: association with metastasis and survival.

21 January 2018

1 reference

The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases

21 January 2018

1 reference

Stromal-derived factor-1alpha/CXCL12-CXCR 4 axis is involved in the dissemination of NSCLC cells into pleural space

21 January 2018

1 reference

Management of small cell lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)

21 January 2018

1 reference

Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo

21 January 2018

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Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells.

21 January 2018

1 reference

Small cell lung carcinoma (SCLC): a clinicopathologic study of 100 cases with surgical specimens

21 January 2018

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Microenvironmental niches in the bone marrow required for B-cell development

21 January 2018

1 reference

CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells.

21 January 2018

1 reference

Involvement of matrix metalloproteinase-9 in stromal cell-derived factor-1/CXCR4 pathway of lung cancer metastasis

21 January 2018

1 reference

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

21 January 2018

1 reference

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

21 January 2018

1 reference

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

21 January 2018

1 reference

A perivascular niche for brain tumor stem cells

21 January 2018

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Hit 'em where they live: targeting the cancer stem cell niche

21 January 2018

1 reference

Identification and expansion of the tumorigenic lung cancer stem cell population

21 January 2018

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Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment

21 January 2018

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Molecular characterisation of side population cells with cancer stem cell-like characteristics in small-cell lung cancer.

21 January 2018

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Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer

21 January 2018

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Drug-selected human lung cancer stem cells: cytokine network, tumorigenic and metastatic properties

21 January 2018

1 reference

Anti-human immunodeficiency virus activity of a novel synthetic peptide, T22 ([Tyr-5,12, Lys-7]polyphemusin II): a possible inhibitor of virus-cell fusion

21 January 2018

1 reference

A novel anti-HIV synthetic peptide, T-22 ([Tyr5,12,Lys7]-polyphemusin II)

21 January 2018

1 reference

Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event

21 January 2018

1 reference

The AMD3100 story: the path to the discovery of a stem cell mobilizer (Mozobil).

21 January 2018

1 reference

A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor

21 January 2018

1 reference

Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4

21 January 2018

1 reference

A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection

21 January 2018

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The bicyclam AMD3100 story

21 January 2018

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Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4.

21 January 2018

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Characterization of the molecular pharmacology of AMD3100: a specific antagonist of the G-protein coupled chemokine receptor, CXCR4.

21 January 2018

1 reference

AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.

21 January 2018

1 reference

Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers

21 January 2018

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Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection.

21 January 2018

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Rapid mobilization of CD34+ cells following administration of the CXCR4 antagonist AMD3100 to patients with multiple myeloma and non-Hodgkin's lymphoma

21 January 2018

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Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction

21 January 2018

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Recent advances on the use of the CXCR4 antagonist plerixafor (AMD3100, Mozobil™) and potential of other CXCR4 antagonists as stem cell mobilizers

21 January 2018

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CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers

21 January 2018

1 reference

Multiple-dose escalation study of the safety, pharmacokinetics, and biologic activity of oral AMD070, a selective CXCR4 receptor inhibitor, in human subjects

21 January 2018

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A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140.

21 January 2018

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Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140.

21 January 2018

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Lipid bilayer simulations of CXCR4 with inverse agonists and weak partial agonists

21 January 2018

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A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists

21 January 2018

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Development of plasmacytoid dendritic cells in bone marrow stromal cell niches requires CXCL12-CXCR4 chemokine signaling.

21 January 2018

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CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells

21 January 2018

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Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5.

21 January 2018

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G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4.

21 January 2018

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Safe use of the CXCR4 inhibitor ALX40-4C in humans

21 January 2018

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CD4-independent infection by HIV-2 is mediated by fusin/CXCR4.

21 January 2018

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CXCR4 chemokine receptor mediates prostate tumor cell adhesion through alpha5 and beta3 integrins

21 January 2018

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Antigenically distinct conformations of CXCR4.

21 January 2018

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The role of post-translational modifications of the CXCR4 amino terminus in stromal-derived factor 1 alpha association and HIV-1 entry

21 January 2018

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Translating an Antagonist of Chemokine Receptor CXCR4: from bench to bedside

21 January 2018

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Increased plasma levels of stromal-derived factor-1 (SDF-1/CXCL12) enhance human thrombopoiesis and mobilize human colony-forming cells (CFC) in NOD/SCID mice

21 January 2018

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Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases

21 January 2018

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Small neutralizing molecules to inhibit actions of the chemokine CXCL12.

21 January 2018

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Strategies for silencing human disease using RNA interference

21 January 2018

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CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1586/ERA.11.11

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24 August 2017

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