(Q52827044)

8 May 2018

title

Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer. (English)

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8 May 2018

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Kevin Spring

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author name string

Farida Ahangari

2

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Shaun P Scott

3

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Paul Waring

4

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David M Purdie

5

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Philip C Chen

6

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Kevin Hourigan

7

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Jonathan Ramsay

8

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Peter J McKinnon

9

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Michael Swift

10

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Martin F Lavin

11

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8 May 2018

language of work or name

English

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publication date

26 August 2002

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8 May 2018

published in

Nature Genetics

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8 May 2018

volume

32

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issue

1

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page(s)

185-190

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describes a project that uses

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https://scigraph.springernature.com/pub.10.1038/ng958

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cites work

The genetic defect in ataxia-telangiectasia

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7 January 2021

ATM: a mediator of multiple responses to genotoxic stress

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7 January 2021

Incidence of cancer in 161 families affected by ataxia-telangiectasia

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7 January 2021

Risk of breast cancer and other cancers in heterozygotes for ataxia-telangiectasia

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7 January 2021

Cancer in patients with ataxia-telangiectasia and in their relatives in the nordic countries

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7 January 2021

Molecular genotyping shows that ataxia-telangiectasia heterozygotes are predisposed to breast cancer

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7 January 2021

Heterozygous ATM mutations do not contribute to early onset of breast cancer

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7 January 2021

Identification of germline missense mutations and rare allelic variants in theATM gene in early-onset breast cancer

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7 January 2021

Increased frequency of ATM mutations in breast carcinoma patients with early onset disease and positive family history

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7 January 2021

Atm-deficient mice: a paradigm of ataxia telangiectasia

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7 January 2021

Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

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7 January 2021

Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system

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7 January 2021

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

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7 January 2021

Mutations at the ataxia-telangiectasia locus and clinical phenotypes of A-T patients

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7 January 2021

Identification of ataxia telangiectasia heterozygotes, a cancer prone population

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7 January 2021

Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype

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7 January 2021

Dominant Negative ATM Mutations in Breast Cancer Families

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7 January 2021

An allelic variant at the ATM locus is implicated in breast cancer susceptibility

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7 January 2021

Ataxia-telangiectasia: phenotype/genotype studies of ATM protein expression, mutations, and radiosensitivity

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7 January 2021

Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia.

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7 January 2021

Predominance of null mutations in ataxia-telangiectasia.

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7 January 2021

Residual ataxia telangiectasia mutated protein function in cells from ataxia telangiectasia patients, with 5762ins137 and 7271T-->G mutations, showing a less severe phenotype.

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7 January 2021

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

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7 January 2021

Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer

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7 January 2021

Atm haploinsufficiency results in increased sensitivity to sublethal doses of ionizing radiation in mice

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7 January 2021

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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7 January 2021

Identifiers

DOI

10.1038/NG958

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8 May 2018

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8 May 2018