(Q52887959)

9 May 2018

title

Analysis of drug metabolism activities in a miniaturized liver cell bioreactor for use in pharmacological studies. (English)

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Katrin Zeilinger

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author name string

Stefan A Hoffmann

1

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Ursula Müller-Vieira

2

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Klaus Biemel

3

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Daniel Knobeloch

4

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Sandra Heydel

5

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Marc Lübberstedt

6

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Andreas K Nüssler

7

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Tommy B Andersson

8

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Jörg C Gerlach

9

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publication date

27 June 2012

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Biotechnology and Bioengineering

published in

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volume

109

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issue

12

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page(s)

3172-3181

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Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes.

cites work

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Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways

21 January 2018

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Dynamic seeding and perfusion culture of hepatocytes with galactosylated vegetable sponge in packed-bed bioreactor.

21 January 2018

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Human hepatocyte functions in a crossed hollow fiber membrane bioreactor

21 January 2018

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The involvement of Kupffer cells in carbon tetrachloride toxicity.

21 January 2018

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Use of primary human liver cells originating from discarded grafts in a bioreactor for liver support therapy and the prospects of culturing adult liver stem cells in bioreactors: a morphologic study

21 January 2018

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Cellular interactions promote tissue-specific function, biomatrix deposition and junctional communication of primary cultured hepatocytes

21 January 2018

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Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions

21 January 2018

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3D hepatic cultures simultaneously maintain primary hepatocyte and liver sinusoidal endothelial cell phenotypes

21 January 2018

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Characterization of rat and human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of diclofenac

21 January 2018

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Extrapolation of diclofenac clearance from in vitro microsomal metabolism data: role of acyl glucuronidation and sequential oxidative metabolism of the acyl glucuronide

21 January 2018

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Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone

21 January 2018

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Extending hepatocyte functionality for drug-testing applications using high-viscosity alginate-encapsulated three-dimensional cultures in bioreactors

21 January 2018

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Hepatocyte dynamics in a three-dimensional rotating bioreactor

21 January 2018

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The effectiveness of a novel cartridge-based bioreactor design in supporting liver cells

21 January 2018

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Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells

21 January 2018

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Primary human hepatocytes on biodegradable poly(l-lactic acid) matrices: a promising model for improving transplantation efficiency with tissue engineering

21 January 2018

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Modular bioreactor for primary human hepatocyte culture: medium flow stimulates expression and activity of detoxification genes.

21 January 2018

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Hepatotoxicity assay using human hepatocytes trapped in microholes of a microfluidic device

21 January 2018

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Time course of primary liver cell reorganization in three-dimensional high-density bioreactors for extracorporeal liver support: an immunohistochemical and ultrastructural study.

21 January 2018

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Scaling down of a clinical three-dimensional perfusion multicompartment hollow fiber liver bioreactor developed for extracorporeal liver support to an analytical scale device useful for hepatic pharmacological in vitro studies.

21 January 2018

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Human Hepatocytes: Isolation, Culture, and Quality Procedures

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIT.24573

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