(Q52901124)

9 May 2018

title

Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis. (English)

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9 May 2018

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Diether Lambrechts

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9 May 2018

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Cédric Blanpain

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9 May 2018

Jean-Christophe Larsimont

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object named as

Jean-Christophe Larsimont

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9 May 2018

Virginie Moers

5

object named as

Virginie Moers

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9 May 2018

author name string

Özdemirhan Serçin

1

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9 May 2018

Andrea E Karambelas

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9 May 2018

Veronique Marthiens

4

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9 May 2018

Bram Boeckx

6

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9 May 2018

Marie Le Mercier

7

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9 May 2018

Renata Basto

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9 May 2018

publication date

23 November 2015

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9 May 2018

published in

Nature Cell Biology

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9 May 2018

volume

18

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9 May 2018

issue

1

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9 May 2018

page(s)

100-110

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9 May 2018

The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin

cites work

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12 December 2020

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

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12 December 2020

Canonical notch signaling functions as a commitment switch in the epidermal lineage

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12 December 2020

Evidence of asymmetric cell division and centrosome inheritance in human neuroblastoma cells

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BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny

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Centrosomes and cilia in human disease.

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Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas

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Centrosome amplification can initiate tumorigenesis in flies.

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Development and homeostasis of the skin epidermis

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12 December 2020

Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation

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12 December 2020

Mechanisms regulating epithelial stratification

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12 December 2020

Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells

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12 December 2020

Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability

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12 December 2020

Plk4-induced centriole biogenesis in human cells

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12 December 2020

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

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12 December 2020

Alterations of the p53 tumor suppressor gene during mouse skin tumor progression

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12 December 2020

Moesin is a major regulator of centrosome behavior in epithelial cells with extra centrosomes

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12 December 2020

Stem-cell hierarchy in skin cancer

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12 December 2020

The centriole duplication cycle

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12 December 2020

Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells

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12 December 2020

Centrosome amplification in tumorigenesis

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12 December 2020

Aurora kinase-A deficiency during skin development impairs cell division and stratification

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12 December 2020

Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer

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12 December 2020

Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability

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12 December 2020

Par3-mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN.

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12 December 2020

Cancer chromosomal instability: therapeutic and diagnostic challenges

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12 December 2020

Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma

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12 December 2020

Centrosome amplification causes microcephaly

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12 December 2020

Mutational inactivation of STAG2 causes aneuploidy in human cancer

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12 December 2020

Aneuploidy acts both oncogenically and as a tumor suppressor

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12 December 2020

Trisomy represses Apc Min -mediated tumours in mouse models of Down’s syndrome

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12 December 2020

Centrosome function in cancer: guilty or innocent?

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12 December 2020

Non-melanoma skin cancer: what drives tumor development and progression?

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12 December 2020

Pituitary hypoplasia in Pttg-/- mice is protective for Rb+/- pituitary tumorigenesis

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12 December 2020

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

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12 December 2020

Asymmetric cell divisions promote stratification and differentiation of mammalian skin

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12 December 2020

Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death

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12 December 2020

Does aneuploidy cause cancer?

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12 December 2020

The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle

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12 December 2020

Centrosome amplification drives chromosomal instability in breast tumor development

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12 December 2020

Centrioles, centrosomes, and cilia in health and disease

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12 December 2020

Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris

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12 December 2020

Sunburn and p53 in the onset of skin cancer

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12 December 2020

Identifiers

DOI

10.1038/NCB3270

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9 May 2018

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9 May 2018