(Q52927960)

30 June 2019

title

Targeting Aurora kinase A and JAK2 prevents GVHD while maintaining Treg and antitumor CTL function. (English)

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30 June 2019

author name string

Brian C Betts

1

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30 June 2019

Anandharaman Veerapathran

2

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30 June 2019

Joseph Pidala

3

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30 June 2019

Hua Yang

4

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30 June 2019

Pedro Horna

5

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30 June 2019

Kelly Walton

6

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30 June 2019

Christopher L Cubitt

7

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30 June 2019

Steven Gunawan

8

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30 June 2019

Harshani R Lawrence

9

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30 June 2019

Nicholas J Lawrence

10

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30 June 2019

Said M Sebti

11

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30 June 2019

Claudio Anasetti

12

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30 June 2019

language of work or name

English

0 references

publication date

1 January 2017

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30 June 2019

Science Translational Medicine

published in

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30 June 2019

volume

9

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30 June 2019

issue

372

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30 June 2019

Selective NFAT targeting in T cells ameliorates GvHD while maintaining antitumor activity

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1 reference

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Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer

21 January 2018

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Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production

21 January 2018

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Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1

21 January 2018

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The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes

21 January 2018

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Tacrolimus/sirolimus vs tacrolimus/methotrexate as GVHD prophylaxis after matched, related donor allogeneic HCT.

21 January 2018

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Prolonged sirolimus administration after allogeneic hematopoietic cell transplantation is associated with decreased risk for moderate-severe chronic graft-versus-host disease

21 January 2018

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A randomized phase II study to evaluate tacrolimus in combination with sirolimus or methotrexate after allogeneic hematopoietic cell transplantation

21 January 2018

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Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells

21 January 2018

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Sirolimus and mycophenolate mofetil as GVHD prophylaxis in myeloablative, matched-related donor hematopoietic cell transplantation

21 January 2018

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The cellular geography of aurora kinases

21 January 2018

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Shared and separate functions of polo-like kinases and aurora kinases in cancer

21 January 2018

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Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention

21 January 2018

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Janus kinase-2 inhibition induces durable tolerance to alloantigen by human dendritic cell-stimulated T cells yet preserves immunity to recall antigen

21 January 2018

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STAT5 polarization promotes iTregs and suppresses human T-cell alloresponses while preserving CTL capacity

21 January 2018

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Pharmacologic blockade of JAK1/JAK2 reduces GvHD and preserves the graft-versus-leukemia effect

21 January 2018

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STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease.

21 January 2018

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Anti-IL6-receptor-alpha (tocilizumab) does not inhibit human monocyte-derived dendritic cell maturation or alloreactive T-cell responses

21 January 2018

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CD4+ T cell STAT3 phosphorylation precedes acute GVHD, and subsequent Th17 tissue invasion correlates with GVHD severity and therapeutic response.

21 January 2018

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Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial.

21 January 2018

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Ruxolitinib is a potent immunosuppressive compound: is it time for anti-infective prophylaxis?

21 January 2018

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The JAK-inhibitor ruxolitinib impairs dendritic cell function in vitro and in vivo

21 January 2018

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Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera.

21 January 2018

1 reference

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Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays

21 January 2018

1 reference

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Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation

21 January 2018

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Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

21 January 2018

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Development of o -Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors

21 January 2018

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A Cell Biologist's Field Guide to Aurora Kinase Inhibitors

21 January 2018

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IL-7 abrogates suppressive activity of human CD4+CD25+FOXP3+ regulatory T cells and allows expansion of alloreactive and autoreactive T cells.

21 January 2018

1 reference

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Functional characterization of alloreactive T cells identifies CD25 and CD71 as optimal targets for a clinically applicable allodepletion strategy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAI8269

Depletion of T regulatory cells through selection of CD127-positive cells results in a population enriched in memory T cells: implications for anti-tumor cell therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAI8269

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAI8269

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAI8269

Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cells

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAI8269

Antibody to the dendritic cell surface activation antigen CD83 prevents acute graft-versus-host disease

21 January 2018

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Immunosuppressive human anti-CD83 monoclonal antibody depletion of activated dendritic cells in transplantation.

21 January 2018

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The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo

21 January 2018

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Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis

21 January 2018

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Comparative outcomes of donor graft CD34+ selection and immune suppressive therapy as graft-versus-host disease prophylaxis for patients with acute myeloid leukemia in complete remission undergoing HLA-matched sibling allogeneic hematopoietic cell t

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAI8269

Single-agent GVHD prophylaxis with posttransplantation cyclophosphamide after myeloablative, HLA-matched BMT for AML, ALL, and MDS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAI8269

Calcein-acetyoxymethyl cytotoxicity assay: standardization of a method allowing additional analyses on recovered effector cells and supernatants

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAI8269

CD28-specific antibody prevents graft-versus-host disease in mice

21 January 2018

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12 December 2020

Interleukin-6 receptor blockade enhances CD39+ regulatory T cell development in rheumatoid arthritis and in experimental arthritis

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12 December 2020

Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease

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12 December 2020

Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey

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12 December 2020

An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin

1 reference

12 December 2020

10.1126/SCITRANSLMED.AAI8269

Identifiers

DOI

1 reference

30 June 2019

PMC publication ID

6368389

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30 June 2019

PubMed publication ID

28077684

1 reference

30 June 2019