(Q53223025)

12 May 2018

title

Combined loss of p21(waf1/cip1) and p27(kip1) enhances tumorigenesis in mice. (English)

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12 May 2018

author name string

Rosa A García-Fernández

1

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12 May 2018

Pilar García-Palencia

2

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12 May 2018

María Á Sánchez

3

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12 May 2018

Gabriel Gil-Gómez

4

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12 May 2018

Belén Sánchez

5

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12 May 2018

Eduardo Rollán

6

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12 May 2018

Juan Martín-Caballero

7

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12 May 2018

Juana M Flores

8

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12 May 2018

publication date

29 August 2011

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12 May 2018

published in

Laboratory Investigation

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12 May 2018

volume

91

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12 May 2018

issue

11

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12 May 2018

page(s)

1634-1642

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12 May 2018

CDK inhibitors: positive and negative regulators of G1-phase progression

cites work

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

PCNA, the maestro of the replication fork

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New functional activities for the p21 family of CDK inhibitors

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

Tumorigenic activity of p21Waf1/Cip1 in thymic lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

p21 in cancer: intricate networks and multiple activities

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

p21 delays tumor onset by preservation of chromosomal stability

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

ATM and p21 cooperate to suppress aneuploidy and subsequent tumor development.

21 January 2018

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p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

p27Kip1 modulates cell migration through the regulation of RhoA activation.

21 January 2018

1 reference

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Expression of the cyclin-dependent kinase inhibitor p27 and its deregulation in mouse B cell lymphomas

21 January 2018

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A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

Loss of the cell cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumorigenesis in knockout mouse models

21 January 2018

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Genetic cooperation between p21Cip1 and INK4 inhibitors in cellular senescence and tumor suppression.

21 January 2018

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Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

Impairment of the p27kip1 function enhances thyroid carcinogenesis in TRK-T1 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

Subcellular localisation of cyclin B, Cdc2 and p21(WAF1/CIP1) in breast cancer. association with prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

Regulation of the cdk inhibitor p27 and its deregulation in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

The tumor suppressor functions of p27(kip1) include control of the mesenchymal/amoeboid transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

Different cooperating effect of p21 or p27 deficiency in combination with INK4a/ARF deletion in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

Anomalous p27kip1 expression in a subset of malignant gliomas

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

7 January 2021

Breast cancer banishes p27 from nucleus

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

7 January 2021

Loss of p27(Kip1) cooperates with cyclin E in T-cell lymphomagenesis

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

7 January 2021

Tumorigenesis in p27/p53- and p18/p53-double null mice: functional collaboration between the pRb and p53 pathways

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

7 January 2021

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

7 January 2021

Prognostic impact of p21/waf1/cip1 in colorectal cancer

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

7 January 2021

Cytoplasmic p21(WAF1/CIP1) expression in human hepatocellular carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.133

7 January 2021

10.1038/LABINVEST.2011.133

Identifiers

DOI

1 reference

12 May 2018

1 reference

12 May 2018