(Q53229738)

12 May 2018

title

Genetic variability at the amyloid-beta precursor protein locus may contribute to the risk of late-onset Alzheimer's disease. (English)

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12 May 2018

author

Peter Holmans

3

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12 May 2018

Alison Goate

12

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12 May 2018

Jordi Pérez-Tur

15

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12 May 2018

Patrick G. Kehoe

object named as

P Kehoe

4

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John Anthony Hardy

14

object named as

J Hardy

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Fabienne Wavrant De Vrieze

12 May 2018

1

object named as

F Wavrant-De Vrièze

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12 May 2018

author name string

R Crook

2

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12 May 2018

M J Owen

5

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12 May 2018

J Williams

6

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12 May 2018

K Roehl

7

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12 May 2018

D K Laliiri

8

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12 May 2018

S Shears

9

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12 May 2018

J Booth

10

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12 May 2018

W Wu

11

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12 May 2018

M C Chartier-Harlin

13

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12 May 2018

language of work or name

English

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publication date

1 July 1999

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12 May 2018

published in

Neuroscience Letters

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12 May 2018

volume

269

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12 May 2018

issue

2

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12 May 2018

page(s)

67-70

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12 May 2018

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

cites work

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Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region.

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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APP gene promoter constructs are preferentially expressed in the CNS and testis of transgenic mice.

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7 January 2021

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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A novel method for making nested deletions and its application for sequencing of a 300 kb region of human APP locus

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The upstream stimulatory factor functionally interacts with the Alzheimer amyloid beta-protein precursor gene

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7 January 2021

An region upstream of the gene promoter for the beta-amyloid precursor protein interacts with proteins from nuclear extracts of the human brain and PC12 cells

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7 January 2021

The promoter activity of the gene encoding Alzheimer β-amyloid precursor protein (APP) is regulated by two blocks of upstream sequences

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7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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Presenilin-1 polymorphism and Alzheimer's disease

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7 January 2021

The expression of the amyloid precursor protein (APP) is regulated by two GC-elements in the promoter

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Molecular mapping of Alzheimer-type dementia in Down's syndrome.

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Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease.

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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7 January 2021

Molecular cloning of the promoter of the gene encoding the Rhesus monkey beta-amyloid precursor protein: structural characterization and a comparative study with other species.

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Functional identification of the promoter of the gene encoding the Rhesus monkey β-amyloid precursor protein

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7 January 2021

The zinc finger protein CTCF binds to the APBbeta domain of the amyloid beta-protein precursor promoter. Evidence for a role in transcriptional activation

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7 January 2021

Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Alzheimer's Disease Collaborative Group

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7 January 2021

Nucleolin and heterogeneous nuclear ribonucleoprotein C proteins specifically interact with the 3'-untranslated region of amyloid protein precursor mRNA

1 reference

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7 January 2021

10.1016/S0304-3940(99)00417-6

Identifiers

DOI

1 reference

12 May 2018

1 reference

12 May 2018