(Q53251211)

12 May 2018

title

Structural assessment of single amino acid mutations: application to TP53 function. (English)

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12 May 2018

author name string

Yum L Yip

1

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12 May 2018

Vincent Zoete

2

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12 May 2018

Holger Scheib

3

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12 May 2018

Olivier Michielin

4

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12 May 2018

publication date

1 September 2006

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12 May 2018

published in

Human Mutation

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12 May 2018

volume

27

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12 May 2018

issue

9

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12 May 2018

page(s)

926-937

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12 May 2018

Automatic procedures for protein design

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Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

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Analysis of void volumes in proteins and application to stability of the p53 tumour suppressor protein

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Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay.

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Characterization of disease-associated single amino acid polymorphisms in terms of sequence and structure properties.

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p300/MDM2 complexes participate in MDM2-mediated p53 degradation

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Analysis of protein-protein interaction sites using surface patches

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Searching for functional sites in protein structures.

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Integrating mutation data and structural analysis of the TP53 tumor-suppressor protein

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Accounting for human polymorphisms predicted to affect protein function

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E2F-1 induces the stabilization of p53 but blocks p53-mediated transactivation.

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7 January 2021

Decision making by p53: life, death and cancer

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7 January 2021

Human non-synonymous SNPs: server and survey

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7 January 2021

Recognition of DNA by p53 Core Domain and Location of Intermolecular Contacts of Cooperative Binding

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7 January 2021

The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo

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7 January 2021

Isolation of Temperature-sensitive p53 Mutations from a Comprehensive Missense Mutation Library

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7 January 2021

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Molecular basis of inherited diseases: a structural perspective

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7 January 2021

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7 January 2021

Towards a structural basis of human non-synonymous single nucleotide polymorphisms

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7 January 2021

Integration of genome data and protein structures: prediction of protein folds, protein interactions and "molecular phenotypes" of single nucleotide polymorphisms

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7 January 2021

Prediction of deleterious human alleles

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7 January 2021

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

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7 January 2021

Structural genomics takes off.

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7 January 2021

Scoring residue conservation

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7 January 2021

SNPs, protein structure, and disease.

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7 January 2021

Three-dimensional structural location and molecular functional effects of missense SNPs in the T cell receptor V? domain

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7 January 2021

Effect of mutation and conformation on the function of p53 in colorectal cancer

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7 January 2021

Phosphorylation regulates the interaction and complex formation between wt p53 protein and PARP-1.

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7 January 2021

Identifiers

DOI

10.1002/HUMU.20379

1 reference

12 May 2018

PubMed ID

16917930

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12 May 2018