(Q53253829)

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Tolfenamic acid inhibits ovarian cancer cell growth and decreases the expression of c-Met and survivin through suppressing specificity protein transcription factors.

scientific article published on 15 April 2011

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28 January 2020

Tolfenamic acid inhibits ovarian cancer cell growth and decreases the expression of c-Met and survivin through suppressing specificity protein transcription factors (English)

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28 January 2020

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Umesh T Sankpal

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28 January 2020

Robert W Holloway

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Robert W Holloway

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28 January 2020

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Sarfraz Ahmad

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28 January 2020

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Riyaz Basha

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28 January 2020

Susan B Ingersoll

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28 January 2020

Cheryl H Baker

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28 January 2020

John R Edwards

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28 January 2020

Sumanth Kaja

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28 January 2020

Maen Abdelrahim

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15 April 2011

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28 January 2020

Gynecologic Oncology

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28 January 2020

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28 January 2020

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28 January 2020

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28 January 2020

Cancer statistics, 2010

1 reference

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Expression of scatter factor and c-met receptor in benign and malignant breast tissue

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Frequent amplification of the c-met gene in scirrhous type stomach cancer.

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The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vitro

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Expression of the c-Met in advanced epithelial ovarian cancer and its prognostic significance

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Overexpression of the Met/HGF receptor in ovarian cancer.

1 reference

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c-Met expression in a gastric cancer cell line producing alpha-fetoprotein

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Activation of c-Met (hepatocyte growth factor receptor) in human gastric cancer tissue

1 reference

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7 January 2021

The HGF receptor c-Met is overexpressed in esophageal adenocarcinoma.

1 reference

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7 January 2021

Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met.

1 reference

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7 January 2021

Targeting the HGF/SF receptor c-met using a hammerhead ribozyme transgene reduces in vitro invasion and migration in prostate cancer cells

1 reference

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7 January 2021

Molecular mechanism of adaphostin-mediated G1 arrest in prostate cancer (PC-3) cells: signaling events mediated by hepatocyte growth factor receptor, c-Met, and p38 MAPK pathways

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7 January 2021

The androgen receptor negatively regulates the expression of c-Met: implications for a novel mechanism of prostate cancer progression

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2011.03.014

7 January 2021

c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2011.03.014

7 January 2021

c-Met overexpression contributes to the acquired apoptotic resistance of nonadherent ovarian cancer cells through a cross talk mediated by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2011.03.014

7 January 2021

An orally available small-molecule inhibitor of c-Met, PF-2341066, reduces tumor burden and metastasis in a preclinical model of ovarian cancer metastasis

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2011.03.014

7 January 2021

Multiple roles of COX-2 in tumor angiogenesis: a target for antiangiogenic therapy

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7 January 2021

Inhibition of angiogenesis by NSAIDs: molecular mechanisms and clinical implications

1 reference

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7 January 2021

Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2011.03.014

7 January 2021

Crucial roles of Sp1 and epigenetic modifications in the regulation of the CLDN4 promoter in ovarian cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2011.03.014

7 January 2021

Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2011.03.014

7 January 2021

Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2011.03.014

7 January 2021

Synergistic cytotoxicity of interferonalpha-2b and interleukin-2 in combination with PBMC against ovarian cancer: development of an experimental model for cellular therapy

1 reference

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7 January 2021

Small inhibitory RNA duplexes for Sp1 mRNA block basal and estrogen-induced gene expression and cell cycle progression in MCF-7 breast cancer cells

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7 January 2021

The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF).

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7 January 2021

Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity

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7 January 2021

Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity

1 reference

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7 January 2021

Downregulation of XIAP expression in ovarian cancer cells induces cell death in vitro and in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2011.03.014

7 January 2021

VEGF- and LPA-induced telomerase in human ovarian cancer cells is Sp1-dependent

1 reference

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7 January 2021

Inhibition of Sp1-dependent transcription and antitumor activity of the new aureolic acid analogues mithramycin SDK and SK in human ovarian cancer xenografts

1 reference

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7 January 2021

Directing cancer cells to self-destruct with pro-apoptotic receptor agonists

1 reference

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Effect of a c-Met-specific, ATP-competitive small-molecule inhibitor SU11274 on human ovarian carcinoma cell growth, motility, and invasion

1 reference

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7 January 2021

Targeting survivin in cancer therapy: fulfilled promises and open questions

1 reference

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7 January 2021

The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter

1 reference

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7 January 2021

Sp1 and Sp3 regulate basal transcription of the survivin gene

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2011.03.014

7 January 2021

Survivin expression in ovarian carcinoma: correlation with apoptotic markers and prognosis.

1 reference

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7 January 2021

Phosphatidylinositol 3-kinase inhibition down-regulates survivin and facilitates TRAIL-mediated apoptosis in neuroblastomas

1 reference

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Regulation of survivin by PI3K/Akt/p70S6K1 pathway

1 reference

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7 January 2021

Identifiers

10.1016/J.YGYNO.2011.03.014

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21496890%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21496890%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

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