(Q53297957)

English

Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic.

scientific article published in November 2008

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scholarly article

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/18987201

Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic. (English)

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/18987201

0 references

1 reference

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inferred from title

Alzheimer's disease

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Sebastian Jimenez

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671312&resulttype=core&format=json

16 May 2020

David Baglietto-Vargas

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671312&resulttype=core&format=json

16 May 2020

Manuel Torres Canalejo

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671312&resulttype=core&format=json

16 May 2020

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671312&resulttype=core&format=json

16 May 2020

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671312&resulttype=core&format=json

16 May 2020

Javier Vitorica

10

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671312&resulttype=core&format=json

16 May 2020

Ines Moreno-Gonzalez

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671312&resulttype=core&format=json

16 May 2020

Antonia Gutierrez

object named as

Antonia Gutierrez

9

1 reference

ORCID Public Data File 2021

author name string

Cristina Caballero

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671312&resulttype=core&format=json

16 May 2020

Raquel Sanchez-Varo

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671312&resulttype=core&format=json

16 May 2020

language of work or name

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publication date

1 November 2008

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/18987201

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671312&resulttype=core&format=json

16 May 2020

28

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671312&resulttype=core&format=json

16 May 2020

45

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671312&resulttype=core&format=json

16 May 2020

11650-11661

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671312&resulttype=core&format=json

16 May 2020

The efficiency of systematic sampling in stereology--reconsidered.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signalin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory therapy for Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vaccination with soluble Abeta oligomers generates toxicity-neutralizing antibodies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial activation in Alzheimer's disease: the role of Abeta and its associated proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrahippocampal LPS injections reduce Abeta load in APP+PS1 transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutralization of TRAIL death pathway protects human neuronal cell line from beta-amyloid toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rofecoxib: no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor death receptor signaling cascade is required for amyloid-beta protein-induced neuron death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation occurs early during the Abeta deposition process in TgCRND8 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time-dependent reduction in Abeta levels after intracranial LPS administration in APP transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minocycline inhibits apoptotic cell death via attenuation of TNF-alpha expression following iNOS/NO induction by lipopolysaccharide in neuron/glia co-cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glia and their cytokines in progression of neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design-based stereology in neuroscience

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia and neuroprotection: implications for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vesicle-mediated transport and release of CCL21 in endangered neurons: a possible explanation for microglia activation remote from a primary lesion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-4 inhibits the expression of mouse formyl peptide receptor 2, a receptor for amyloid beta1-42, in TNF-alpha-activated microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of microglial neurotoxicity by the fractalkine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical and functional characterization of three activated macrophage populations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of the tumor necrosis factor-related apoptosis inducing ligand death receptor DR5 prevents beta-amyloid neurotoxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoclonal antibodies that target pathological assemblies of Abeta.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Solution state characterization of amyloid beta-derived diffusible ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-17 family cytokines and the expanding diversity of effector T cell lineages

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammatory processes in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inter-individual variability in the expression of the mutated form of hPS1M146L determined the production of Abeta peptides in the PS1xAPP transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-4 attenuates the neuroinflammation induced by amyloid-beta in vivo and in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated neuronal expression of CD200 protects Wlds mice from inflammation-mediated neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Connecting TNF-alpha signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by amyloid beta protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of nucleotides in the neuron--glia communication responsible for the brain functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased fractalkine and increased IP-10 expression in aged brain of APP(swe) transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TRAIL-related neurotoxicity implies interaction with the Wnt pathway in human neuronal cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular and pharmacological characterization of native cortical gamma-aminobutyric acidA receptors containing both alpha1 and alpha3 subunits.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial-neuronal interactions in Alzheimer's disease: the potential role of a 'cytokine cycle' in disease progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/18987201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3024-08.2008

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671312&resulttype=core&format=json

16 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671312&resulttype=core&format=json

16 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671312&resulttype=core&format=json

16 May 2020

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