(Q53451934)

14 May 2018

review article

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title

Cyclin-dependent kinases and cell-cycle transitions: does one fit all? (English)

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14 May 2018

Helfrid Hochegger

1

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Shunichi Takeda

object named as

Shunichi Takeda

series ordinal

2

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author name string

Tim Hunt

series ordinal

3

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14 May 2018

publication date

24 September 2008

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14 May 2018

Nature Reviews Molecular Cell Biology

published in

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14 May 2018

volume

9

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14 May 2018

page(s)

910-916

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14 May 2018

issue

11

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14 May 2018

https://scigraph.springernature.com/pub.10.1038/nrm2510

exact match

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cites work

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Cdk2 knockout mice are viable

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Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B.

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Multiple protein phosphatases are required for mitosis in Drosophila.

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Active cyclin B1-Cdk1 first appears on centrosomes in prophase

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A positive-feedback-based bistable 'memory module' that governs a cell fate decision

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Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase

31 March 2020

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Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

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Comparative conservation analysis of the human mitotic phosphoproteome

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Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

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Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity

31 March 2020

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Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

31 March 2020

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Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRM2510

1 reference

14 May 2018

PubMed ID

18813291

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14 May 2018