(Q53460407)

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Combined deletions of amyloid precursor protein and amyloid precursor-like protein 2 reveal different effects on mouse brain metal homeostasis.

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Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/24448592

Combined deletions of amyloid precursor protein and amyloid precursor-like protein 2 reveal different effects on mouse brain metal homeostasis. (English)

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/24448592

3

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/24448592

author name string

B Elise Needham

1

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/24448592

Giuseppe D Ciccotosto

2

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/24448592

publication date

21 January 2014

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/24448592

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/24448592

6

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/24448592

3

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/24448592

598-603

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/24448592

Physiological functions of APP family proteins

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

The beta A4 amyloid precursor protein binding to copper.

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

Rapid induction of Alzheimer A beta amyloid formation by zinc.

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

Metal binding dictates conformation and function of the amyloid precursor protein (APP) E2 domain

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

In vivo reduction of amyloid-beta by a mutant copper transporter

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

The mouse APLP2 gene. Chromosomal localization and promoter characterization

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

Bioimaging of copper alterations in the aging mouse brain by autoradiography, laser ablation inductively coupled plasma mass spectrometry and immunohistochemistry

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

The distribution profile and oxidation states of biometals in APP transgenic mouse brain: dyshomeostasis with age and as a function of the development of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

Identification and regulation of the high affinity binding site of the Alzheimer's disease amyloid protein precursor (APP) to glycosaminoglycans

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

Interaction between the zinc (II) and the heparin binding site of the Alzheimer's disease beta A4 amyloid precursor protein (APP).

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-Nitric Oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

Divalent metal transporter 1 is involved in amyloid precursor protein processing and Abeta generation

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

The amyloid precursor protein copper binding domain histidine residues 149 and 151 mediate APP stability and metabolism.

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

APP physiological and pathophysiological functions: insights from animal models.

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function.

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00358B

21 January 2018

Identifiers

10.1039/C3MT00358B

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/24448592

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/24448592

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