(Q53475844)

14 May 2018

title

Effect of CYP2B6 genotype on the pharmacokinetics of sibutramine and active metabolites in healthy subjects. (English)

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14 May 2018

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Jae Yong Chung

1

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14 May 2018

Seong Bok Jang

2

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14 May 2018

Yoon Jung Lee

3

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14 May 2018

Min Soo Park

4

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14 May 2018

Kyungsoo Park

5

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14 May 2018

publication date

29 March 2010

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14 May 2018

The Journal of Clinical Pharmacology

published in

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14 May 2018

volume

51

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14 May 2018

page(s)

53-59

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14 May 2018

issue

1

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14 May 2018

Prediction of successful weight reduction under sibutramine therapy through genotyping of the G-protein beta3 subunit gene (GNB3) C825T polymorphism

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Sibutramine pharmacokinetics in young and elderly healthy subjects.

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The contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutramine hydrochloride

21 January 2018

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Cytochrome P450 2B6 catalyzes the formation of pharmacologically active sibutramine (N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine) metabolites in human liver microsomes

21 January 2018

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Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6

21 January 2018

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Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270010362906

Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance

21 January 2018

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Impact of CYP2B6 polymorphism on hepatic efavirenz metabolism in vitro.

21 January 2018

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Aberrant splicing caused by single nucleotide polymorphism c.516G>T [Q172H], a marker of CYP2B6*6, is responsible for decreased expression and activity of CYP2B6 in liver

21 January 2018

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Functional characterization of cytochrome P450 2B6 allelic variants

21 January 2018

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Predictive value of known and novel alleles of CYP2B6 for efavirenz plasma concentrations in HIV-infected individuals.

21 January 2018

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Haplotype structure and allele frequencies of CYP2B6 in a Korean population.

21 January 2018

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Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes

21 January 2018

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Cytochrome P450 2B6 activity as measured by bupropion hydroxylation: effect of induction by rifampin and ethnicity

21 January 2018

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Sibutramine produces dose-related weight loss.

21 January 2018

1 reference

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Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects

21 January 2018

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Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain

21 January 2018

1 reference

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Association of CYP2B6, CYP3A5, and CYP2C19 Genetic Polymorphisms With Sibutramine Pharmacokinetics in Healthy Korean Subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270010362906

21 January 2018

Identifiers

DOI

10.1177/0091270010362906

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14 May 2018

PubMed ID

20350955

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14 May 2018