(Q53534176)

15 May 2018

title

The ubiquitin ligase APC(Cdh1) is required to maintain genome integrity in primary human cells. (English)

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15 May 2018

author name string

D Engelbert

1

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15 May 2018

D Schnerch

2

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15 May 2018

A Baumgarten

3

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15 May 2018

R Wäsch

4

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15 May 2018

language of work or name

English

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publication date

13 August 2007

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15 May 2018

published in

Oncogene

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15 May 2018

volume

27

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15 May 2018

issue

7

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15 May 2018

page(s)

907-917

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15 May 2018

https://scigraph.springernature.com/pub.10.1038/sj.onc.1210703

exact match

0 references

cites work

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

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7 January 2021

Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210703

7 January 2021

A system for stable expression of short interfering RNAs in mammalian cells

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7 January 2021

The cellular geography of aurora kinases

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7 January 2021

A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers.

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7 January 2021

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

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7 January 2021

Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells

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7 January 2021

Two Redundant Oscillatory Mechanisms in the Yeast Cell Cycle

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7 January 2021

Regulation of early events in chromosome replication

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7 January 2021

A third-generation lentivirus vector with a conditional packaging system

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7 January 2021

Tumour biology: Policing of oncogene activity by p53

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210703

7 January 2021

Deregulation of cyclin E in human cells interferes with prereplication complex assembly

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210703

7 January 2021

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

1 reference

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7 January 2021

Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.

1 reference

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7 January 2021

Rules for making human tumor cells

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7 January 2021

The anaphase-promoting complex: it's not just for mitosis any more.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210703

7 January 2021

Ubiquitin and ubiquitin-like proteins in cancer pathogenesis

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7 January 2021

Resolution of anaphase bridges in cancer cells

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7 January 2021

Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210703

7 January 2021

The yeast CDK inhibitor Sic1 prevents genomic instability by promoting replication origin licensing in late G(1)

1 reference

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7 January 2021

Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells

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7 January 2021

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

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7 January 2021

Regulation of the APC and the exit from mitosis

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7 January 2021

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

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7 January 2021

Separase-mediated cleavage of cohesin at interphase is required for DNA repair

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7 January 2021

siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference

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7 January 2021

Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships

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7 January 2021

The anaphase promoting complex/cyclosome: a machine designed to destroy

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210703

7 January 2021

Inactivation of hCDC4 can cause chromosomal instability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210703

7 January 2021

Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210703

7 January 2021

The processivity of multiubiquitination by the APC determines the order of substrate degradation.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210703

7 January 2021

Securin is a target of the UV response pathway in mammalian cells

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7 January 2021

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

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7 January 2021

Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210703

7 January 2021

The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210703

7 January 2021

Deregulated cyclin E induces chromosome instability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210703

7 January 2021

Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210703

7 January 2021

Degradation of human Aurora-A protein kinase is mediated by hCdh1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210703

7 January 2021

Primary fibroblasts from human adults as target cells for ex vivo transfection and gene therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210703

7 January 2021

Alterations of anaphase-promoting complex genes in human colon cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210703

7 January 2021

APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210703

7 January 2021

Anaphase-promoting complex-dependent proteolysis of cell cycle regulators and genomic instability of cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210703

7 January 2021

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210703

7 January 2021

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210703

7 January 2021

Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210703

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210703

1 reference

15 May 2018

PubMed ID

17700535

1 reference

15 May 2018