(Q36002265)

11 August 2017

1 reference

title

Anaphase-promoting complex-dependent proteolysis of cell cycle regulators and genomic instability of cancer cells (English)

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11 August 2017

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Ralph Wäsch

1

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11 August 2017

Dirk Engelbert

series ordinal

2

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11 August 2017

language of work or name

English

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publication date

1 January 2005

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11 August 2017

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11 August 2017

volume

24

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11 August 2017

issue

1

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11 August 2017

page(s)

1-10

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1208017

11 August 2017

exact match

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cites work

Men and sin: what's the difference?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

The cellular geography of aurora kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

Activity of the APC(Cdh1) form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20p

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

Chromosome segregation and cancer: cutting through the mystery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

Cyclin E and survival in patients with breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

Regulation of APC activity by phosphorylation and regulatory factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

To cycle or not to cycle: a critical decision in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

The spindle checkpoint: structural insights into dynamic signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

The roles of Fzy/Cdc20 and Fzr/Cdh1 in regulating the destruction of cyclin B in space and time

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

A phase 2 study of bortezomib in relapsed, refractory myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

Down-regulation of Cdc6, a cell cycle regulatory gene, in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

Cdc28 activates exit from mitosis in budding yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

Chromosomal instability and cytoskeletal defects in oral cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

Phase I clinical and pharmacokinetic study of flavopiridol administered as a daily 1-hour infusion in patients with advanced neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

Mad2 transiently associates with an APC/p55Cdc complex during mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

CDK1 inactivation regulates anaphase spindle dynamics and cytokinesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

Improved cervical smear assessment using antibodies against proteins that regulate DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

Cyclin A in cell cycle control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

Nuclear localization of the cell cycle regulator CDH1 and its regulation by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

The proteasome: a novel target for cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Evidence of chromosomal instability in prostate cancer determined by spectral karyotyping (SKY) and interphase fish analysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Mutations of mitotic checkpoint genes in human cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Degradation of cyclin B is required for the onset of anaphase in Mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Cyclin is degraded by the ubiquitin pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Mismatch repair deficiency in hematological malignancies with microsatellite instability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Aurora2/BTAK/STK15 is involved in cell cycle checkpoint and cell survival of aggressive non‐Hodgkin's lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Cell cycle control and cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Cohesin cleavage by separase required for anaphase and cytokinesis in human cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

1 reference

7 January 2021

Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Budding yeast Cdc20: a target of the spindle checkpoint.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Securin is required for chromosomal stability in human cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

How proteolysis drives the cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

How the cyclin became a cyclin: regulated proteolysis in the cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Cdh1-APC controls axonal growth and patterning in the mammalian brain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Genetic instability in colorectal cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Genetic instabilities in human cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Inhibition of F-Box protein p45(SKP2) expression and stabilization of cyclin-dependent kinase inhibitor p27(KIP1) in vitamin D analog-treated cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Chromosome instability in human lung cancers: possible underlying mechanisms and potential consequences in the pathogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Inactivation of hCDC4 can cause chromosomal instability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Interfaces between the detection, signaling, and repair of DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

hBUB1 defects in leukemia and lymphoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Expression of hpttg proto-oncogene in lymphoid neoplasias

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Overexpression of B-type cyclins alters chromosomal segregation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Yeast Hct1 is a regulator of Clb2 cyclin proteolysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Amplification/overexpression of a mitotic kinase gene in human bladder cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

1 reference

7 January 2021

APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Deregulated cyclin E induces chromosome instability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Dual inhibition of sister chromatid separation at metaphase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Cell cycle control of DNA replication.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Cyclin E and prognosis in patients with breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Alterations of anaphase-promoting complex genes in human colon cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Phosphorylation of Cdc20/fizzy negatively regulates the mammalian cyclosome/APC in the mitotic checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208017

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1208017

1 reference

11 August 2017

1 reference