(Q53547949)

15 May 2018

title

RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factors. (English)

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15 May 2018

author name string

Seetha V Srinivasan

1

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15 May 2018

Christopher N Mayhew

2

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15 May 2018

Sandy Schwemberger

3

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15 May 2018

William Zagorski

4

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15 May 2018

Erik S Knudsen

5

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15 May 2018

language of work or name

English

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publication date

6 June 2007

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15 May 2018

Journal of Biological Chemistry

published in

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15 May 2018

volume

282

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15 May 2018

issue

33

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15 May 2018

page(s)

23867-23877

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15 May 2018

Alterations in G1/S cell-cycle control contributing to carcinogenesis.

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

The retinoblastoma protein pathway in cell cycle control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

The retinoblastoma protein pathway and the restriction point

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

The retinoblastoma tumour suppressor in development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

RB and cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Distinct mechanisms for regulating the tumor suppressor and antiapoptotic functions of Rb.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Regulation of the G1/S phase of the cell cycle and alterations in the RB pathway in human lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

A revised picture of the E2F transcriptional network and RB function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

RB reversibly inhibits DNA replication via two temporally distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

DNA replication in eukaryotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Initiation of DNA replication in eukaryotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Cell cycle control of DNA replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Origin recognition and the chromosome cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Preventing re-replication of chromosomal DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Right place, right time, and only once: replication initiation in metazoans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

DNA replication and progression through S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

A dynamic model for replication protein A (RPA) function in DNA processing pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Regulation of early events in chromosome replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Retinoblastoma tumor suppressor protein signals through inhibition of cyclin-dependent kinase 2 activity to disrupt PCNA function in S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Active Localization of the Retinoblastoma Protein in Chromatin and Its Response to S Phase DNA Damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

DNA damage invokes mismatch repair-dependent cyclin D1 attenuation and retinoblastoma signaling pathways to inhibit CDK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Discrete signaling pathways participate in RB-dependent responses to chemotherapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

The spindle checkpoint, aneuploidy, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

21 January 2018

Aneuploidy and cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

From polyploidy to aneuploidy, genome instability and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Retinoblastoma tumor suppressor and genome stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

RB silencing compromises the DNA damage-induced G2/M checkpoint and causes deregulated expression of the ECT2 oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Differential role of RB in response to UV and IR damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Distinct action of the retinoblastoma pathway on the DNA replication machinery defines specific roles for cyclin-dependent kinase complexes in prereplication complex assembly and S-phase progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Licensing of DNA replication by a multi-protein complex of MCM/P1 proteins in Xenopus eggs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

On the road to cancer: aneuploidy and the mitotic checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

DNA replication licensing in somatic and germ cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Cell Division, a new open access online forum for and from the cell cycle community

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Regulation of CDC6, geminin, and CDT1 in human cells that undergo polyploidization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

A p53-dependent checkpoint pathway prevents rereplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Cyclin A is a functional target of retinoblastoma tumor suppressor protein-mediated cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Functional antagonism between E2F family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

The regulation of E2F by pRB-family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Distinctions in the specificity of E2F function revealed by gene expression signatures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Cell cycle, proteolysis and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Dynamics of pre-replication complex proteins during the cell division cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

RB-dependent S-phase response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Geminin becomes activated as an inhibitor of Cdt1/RLF-B following nuclear import.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

G1 tetraploidy checkpoint and the suppression of tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

The retinoblastoma protein regulates pericentric heterochromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Licensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

MCM proteins and DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

The retinoblastoma gene: a prototypic and multifunctional tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

DNA replication control through interaction of E2F-RB and the origin recognition complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Nuclear organization of DNA replication in primary mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Stable low-level expression of p21WAF1/CIP1 in A549 human bronchogenic carcinoma cell line-derived clones down-regulates E2F1 mRNA and restores cell proliferation control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Centrosome amplification induced by hydroxyurea leads to aneuploidy in pRB deficient human and mouse fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Role of Rb family in the epigenetic definition of chromatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

Guilt by association? p53 and the development of aneuploidy in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700542200

21 January 2018

Identifiers

DOI

10.1074/JBC.M700542200

1 reference

15 May 2018

PubMed ID

17556357

1 reference

15 May 2018