(Q53668637)

17 May 2018

title

Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function. (English)

1 reference

17 May 2018

1 reference

Mark Morris

1

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17 May 2018

Peter Hepburn

series ordinal

2

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17 May 2018

David Wynford-Thomas

series ordinal

3

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17 May 2018

language of work or name

English

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publication date

1 June 2002

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17 May 2018

published in

Oncogene

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17 May 2018

volume

21

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17 May 2018

page(s)

4277-4288

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17 May 2018

issue

27

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17 May 2018

https://scigraph.springernature.com/pub.10.1038/sj.onc.1205492

exact match

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cites work

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p14ARF links the tumour suppressors RB and p53.

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Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis

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Tumor suppressors and oncogenes in cellular senescence.

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Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts

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The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor

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Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

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Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1.

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Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

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Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

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The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2.

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Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells

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Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

21 January 2018

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Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts

21 January 2018

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Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

21 January 2018

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Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas

21 January 2018

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Proliferative lifespan checkpoints: cell-type specificity and influence on tumour biology

21 January 2018

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Characteristics of genomic breakpoints in TLS-CHOP translocations in liposarcomas suggest the involvement of Translin and topoisomerase II in the process of translocation

21 January 2018

1 reference

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7 January 2021

Complex mechanisms underlying impaired activation of Cdk4 and Cdk2 in replicative senescence: roles of p16, p21, and cyclin D1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205492

7 January 2021

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205492

7 January 2021

Molecular abnormalities in liposarcoma: role of MDM2 and CDK4-containing amplicons at 12q13-22

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205492

7 January 2021

The p16INK4a/CDKN2A tumor suppressor and its relatives.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205492

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205492

1 reference

17 May 2018

PubMed ID

12082615

1 reference

17 May 2018