(Q53704198)

18 May 2018

title

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. (English)

1 reference

18 May 2018

0 references

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16

Ralph S Baric

1 reference

18 May 2018

14

Richard L Mackman

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18 May 2018

Robert Jordan

10

Robert Jordan

1 reference

18 May 2018

Mark R. Denison

17

Mark R Denison

1 reference

18 May 2018

Maria Luisa Agostini

1

Maria L Agostini

1 reference

18 May 2018

Timothy P Sheahan

5

Timothy P Sheahan

1 reference

18 May 2018

James Brett Case

8

James Brett Case

1 reference

18 May 2018

Tomáš Cihlář

12

Tomas Cihlar

1 reference

18 May 2018

13

Dustin Siegel

1 reference

18 May 2018

Rachel L. Graham

4

Rachel L Graham

1 reference

18 May 2018

Amy C Sims

3

Amy C Sims

1 reference

18 May 2018

Michael O Clarke

15

Michael O Clarke

1 reference

18 May 2018

Adrian S. Ray

11

Adrian S Ray

1 reference

18 May 2018

Erica L Andres

2

Erica L Andres

1 reference

18 May 2018

Joy Y Feng

9

Joy Y Feng

1 reference

18 May 2018

author name string

Xiaotao Lu

6

1 reference

18 May 2018

Everett Clinton Smith

7

1 reference

18 May 2018

language of work or name

English

0 references

publication date

6 March 2018

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18 May 2018

published in

mBio

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18 May 2018

volume

9

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18 May 2018

issue

2

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18 May 2018

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

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GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses

19 May 2018

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19 May 2018

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Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens

19 May 2018

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BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease

19 May 2018

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19 May 2018

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19 May 2018

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19 May 2018

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L159F and V321A Sofosbuvir-Associated Hepatitis C Virus NS5B Substitutions.

19 May 2018

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19 May 2018

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Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and Resistance

19 May 2018

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Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease

19 May 2018

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Coronaviruses: an overview of their replication and pathogenesis.

19 May 2018

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One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

19 May 2018

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Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus

19 May 2018

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A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant

19 May 2018

1 reference

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Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.

19 May 2018

1 reference

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SARS-CoV ORF1b-encoded nonstructural proteins 12-16: replicative enzymes as antiviral targets.

19 May 2018

1 reference

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Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus

19 May 2018

1 reference

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Clinical management and infection control of SARS: lessons learned

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Mechanism of action of T-705 ribosyl triphosphate against influenza virus RNA polymerase

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

T-705 (favipiravir) induces lethal mutagenesis in influenza A H1N1 viruses in vitro

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Mechanism of action of ribavirin in the treatment of chronic hepatitis C.

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Arbovirus high fidelity variant loses fitness in mosquitoes and mice

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

A time-of-drug addition approach to target identification of antiviral compounds

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

In vivo fitness cost of the M184V mutation in multidrug-resistant human immunodeficiency virus type 1 in the absence of lamivudine

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

The Mechanism of Action of -D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine Involves a Second Metabolic Pathway Leading to -D-2'-Deoxy-2'-Fluoro-2'-C-Methyluridine 5'-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

19 May 2018

1 reference

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Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants.

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Sequential structures provide insights into the fidelity of RNA replication

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

SARS: systematic review of treatment effects

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Inhibition of human coronavirus NL63 infection at early stages of the replication cycle

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: role of ciliated cells in viral spread in the conducting airways of the lungs

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Increased fidelity reduces poliovirus fitness and virulence under selective pressure in mice

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug design

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

A novel coronavirus associated with severe acute respiratory syndrome

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59.

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

The M184V mutation in HIV-1 reverse transcriptase (RT) conferring lamivudine resistance does not result in broad cross-resistance to nucleoside analogue RT inhibitors.

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Higher fidelity of RNA-dependent DNA mispair extension by M184V drug-resistant than wild-type reverse transcriptase of human immunodeficiency virus type 1.

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Inhibition of purified human and herpes simplex virus-induced DNA polymerases by 9-(2-hydroxyethoxymethyl)guanine triphosphate. Effects on primer-template function

19 May 2018

1 reference

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Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent

19 May 2018

1 reference

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Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA.

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Well-differentiated human airway epithelial cell cultures.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Antiviral activity of nucleoside analogues against SARS-coronavirus (SARS-coV)

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5844999

Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase

2 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29511076

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MBIO.00221-18

1 reference

18 May 2018

0 references

1 reference

18 May 2018

PubMed ID

29511076

1 reference

18 May 2018