(Q53730976)

18 May 2018

title

Probing the conformation of the prion protein within a single amyloid fibril using a novel immunoconformational assay. (English)

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18 May 2018

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7

Ilia V Baskakov

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18 May 2018

author name string

Vera Novitskaya

1

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18 May 2018

Natallia Makarava

2

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Anne Bellon

3

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Olga V Bocharova

4

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Igor B Bronstein

5

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R Anthony Williamson

6

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language of work or name

English

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publication date

27 March 2006

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18 May 2018

Journal of Biological Chemistry

published in

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18 May 2018

volume

281

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issue

22

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18 May 2018

page(s)

15536-15545

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18 May 2018

Shattuck lecture--neurodegenerative diseases and prions

cites work

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Molecular classification of sporadic Creutzfeldt-Jakob disease.

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Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity

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Eight prion strains have PrP(Sc) molecules with different conformations

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Strain-specified relative conformational stability of the scrapie prion protein

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Strain-dependent differences in beta-sheet conformations of abnormal prion protein

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Coexistence of multiple PrPSc types in individuals with Creutzfeldt-Jakob disease

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Detection of type 1 prion protein in variant Creutzfeldt-Jakob disease

21 January 2018

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A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform

21 January 2018

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A prion protein epitope selective for the pathologically misfolded conformation

21 January 2018

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Effects of different experimental conditions on the PrPSc core generated by protease digestion: implications for strain typing and molecular classification of CJD.

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Synthetic mammalian prions

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Strain-specified characteristics of mouse synthetic prions

21 January 2018

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Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

21 January 2018

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3D structure of Alzheimer's amyloid-beta(1-42) fibrils

21 January 2018

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Parallel beta-sheets and polar zippers in amyloid fibrils formed by residues 10-39 of the yeast prion protein Ure2p

21 January 2018

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Correlation of structural elements and infectivity of the HET-s prion

21 January 2018

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Antibodies inhibit prion propagation and clear cell cultures of prion infectivity

21 January 2018

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Immobilized prion protein undergoes spontaneous rearrangement to a conformation having features in common with the infectious form

21 January 2018

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In vitro conversion of full-length mammalian prion protein produces amyloid form with physical properties of PrP(Sc).

21 January 2018

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Synthetic prions generated in vitro are similar to a newly identified subpopulation of PrPSc from sporadic Creutzfeldt-Jakob Disease

21 January 2018

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Motif-grafted antibodies containing the replicative interface of cellular PrP are specific for PrPSc

21 January 2018

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Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice

21 January 2018

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Abbreviated incubation times for human prions in mice expressing a chimeric mouse-human prion protein transgene

21 January 2018

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Mutant PrPSc conformers induced by a synthetic peptide and several prion strains

21 January 2018

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Evolution of a strain of CJD that induces BSE-like plaques

21 January 2018

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Changing a single amino acid in the N-terminus of murine PrP alters TSE incubation time across three species barriers

21 January 2018

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Pathway complexity of prion protein assembly into amyloid

21 January 2018

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Prions: so many fibers, so little infectivity

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M601349200

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18 May 2018

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18 May 2018