(Q53761895)

19 May 2018

title

Conformation of paired helical filaments blocks dephosphorylation of epitopes shared with fetal tau except Ser199/202 and Ser202/Thr205. (English)

1 reference

19 May 2018

author name string

W Gordon-Krajcer

series ordinal

1

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19 May 2018

L Yang

series ordinal

2

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19 May 2018

H Ksiezak-Reding

series ordinal

3

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19 May 2018

language of work or name

English

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publication date

1 February 2000

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19 May 2018

number of pages

13

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inferred from page(s)

published in

Brain Research

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19 May 2018

volume

856

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19 May 2018

issue

1-2

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19 May 2018

page(s)

163-175

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19 May 2018

Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease

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Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205.

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Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms

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Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

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Tau protein becomes long and stiff upon phosphorylation: correlation between paracrystalline structure and degree of phosphorylation

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Alzheimer-like changes in microtubule-associated protein Tau induced by sulfated glycosaminoglycans. Inhibition of microtubule binding, stimulation of phosphorylation, and filament assembly depend on the degree of sulfation

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The extent of phosphorylation of fetal tau is comparable to that of PHF-tau from Alzheimer paired helical filaments

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Epitopes that span the tau molecule are shared with paired helical filaments.

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Tau immunoreactivity and SDS solubility of two populations of paired helical filaments that differ in morphology

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Binding of Alz 50 depends on Phe8 in tau synthetic peptides and varies between native and denatured tau proteins.

7 January 2021

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Mass and physical dimensions of two distinct populations of paired helical filaments.

7 January 2021

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Casein kinase 1 is tightly associated with paired-helical filaments isolated from Alzheimer's disease brain.

7 January 2021

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Protein phosphatase 1 is targeted to microtubules by the microtubule-associated protein Tau.

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Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

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Differential sensitivity to proteolysis by brain calpain of adult human tau, fetal human tau and PHF-tau

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Proline-directed and non-proline-directed phosphorylation of PHF-tau.

7 January 2021

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Dephosphorylation of abnormal sites of tau factor by protein phosphatases and its implication for Alzheimer's disease.

7 January 2021

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Expression of protein phosphatases (PP-1, PP-2A, PP-2B and PTP-1B) and protein kinases (MAP kinase and P34cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals.

7 January 2021

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Subcellular distribution of protein phosphatases and abnormally phosphorylated tau in the temporal cortex from Alzheimer's disease and control brains

7 January 2021

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Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration

7 January 2021

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7 January 2021

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Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

7 January 2021

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Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament Tau

7 January 2021

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Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A.

7 January 2021

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Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies

7 January 2021

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Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites

7 January 2021

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A protein kinase associated with paired helical filaments in Alzheimer disease

7 January 2021

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Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain

7 January 2021

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Mitotic phosphoepitopes precede paired helical filaments in Alzheimer's disease

7 January 2021

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Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B.

7 January 2021

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Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1.

7 January 2021

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Dephosphorylation of fetal-tau and paired helical filaments-tau by protein phosphatases 1 and 2A and calcineurin

7 January 2021

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Calpain‐Induced Proteolysis of Normal Human Tau and Tau Associated with Paired Helical Filaments

7 January 2021

1 reference

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Tau in paired helical filaments is functionally distinct from fetal tau: assembly incompetence of paired helical filament-tau

7 January 2021

1 reference

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Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902391-4

Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: focusing on phosphatases

7 January 2021

1 reference

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7 January 2021

inferred from DOI database lookup

Tau released from paired helical filaments with formic acid or guanidine is susceptible to calpain-mediated proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902391-4

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1016/S0006-8993(99)02391-4

1 reference

19 May 2018

1 reference

19 May 2018