(Q53845126)

20 May 2018

title

Mutations that perturb cyclophilin A ligand binding pocket confer cyclosporin A resistance in Saccharomyces cerevisiae. (English)

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20 May 2018

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Saccharomyces cerevisiae

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Cardenas ME

1

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20 May 2018

Lim E

series ordinal

2

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20 May 2018

Heitman J

series ordinal

3

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20 May 2018

language of work or name

English

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publication date

1 September 1995

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20 May 2018

Journal of Biological Chemistry

published in

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20 May 2018

volume

270

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20 May 2018

issue

36

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20 May 2018

page(s)

20997-21002

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20 May 2018

The mechanism of action of cyclosporin A and FK506

cites work

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https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains

21 January 2018

1 reference

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Calcineurin-dependent growth control in Saccharomyces cerevisiae mutants lacking PMC1, a homolog of plasma membrane Ca2+ ATPases

21 January 2018

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Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location

21 January 2018

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase

21 January 2018

1 reference

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Identification and molecular characterization of the calmodulin‐binding subunit gene (CMP1) of protein phosphatase 2B from Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Regulatory subunit (CNB1 gene product) of yeast Ca2+/calmodulin-dependent phosphoprotein phosphatases is required for adaptation to pheromone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

21 January 2018

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Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Calcineurin-dependent growth of an FK506- and CsA-hypersensitive mutant of Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Crystal structure of recombinant human T-cell cyclophilin A at 2.5 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

X-ray structure of a decameric cyclophilin-cyclosporin crystal complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

X-ray structure of a monomeric cyclophilin A-cyclosporin A crystal complex at 2.1 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

The X-ray structure of a tetrapeptide bound to the active site of human cyclophilin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Crystal structure of cyclophilin A complexed with substrate Ala-Pro suggests a solvent-assisted mechanism of cis-trans isomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

The X-ray structure of (MeBm2t)1-cyclosporin complexed with cyclophilin A provides an explanation for its anomalously high immunosuppressive activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Isotope-edited NMR of cyclosporin A bound to cyclophilin: evidence for a trans 9,10 amide bond.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Three-dimensional solution structure of Escherichia coli periplasmic cyclophilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

The mutant Escherichia coli F112W cyclophilin binds cyclosporin A in nearly identical conformation as human cyclophilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A and delineation of its calcineurin-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Crystal structure of murine cyclophilin C complexed with immunosuppressive drug cyclosporin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Peptidyl-prolyl cis-trans-isomerase from Escherichia coli: a periplasmic homolog of cyclophilin that is not inhibited by cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Two distinct forms of peptidylprolyl-cis-trans-isomerase are expressed separately in periplasmic and cytoplasmic compartments of Escherichia coli cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Human and Escherichia coli cyclophilins: sensitivity to inhibition by the immunosuppressant cyclosporin A correlates with a specific tryptophan residue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Active site mutants of human cyclophilin A separate peptidyl-prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Cyclophilin residues that affect noncompetitive inhibition of the protein serine phosphatase activity of calcineurin by the cyclophilin.cyclosporin A complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

The ninaA gene required for visual transduction in Drosophila encodes a homologue of cyclosporin A-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Drosophila ninaA gene encodes an eye-specific cyclophilin (cyclosporine A binding protein)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Peptidyl-prolyl cis-trans isomerases, cyclophilin, FK506-binding protein, and ninaA: four of a kind

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

The cyclophilin homolog ninaA is a tissue-specific integral membrane protein required for the proper synthesis of a subset of Drosophila rhodopsins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

The cyclophilin homolog ninaA is required in the secretory pathway

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Sensitivity to cyclosporin A is mediated by cyclophilin in Neurospora crassa and Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Yeast cyclophilin: isolation and characterization of the protein, cDNA and gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Cyclophilin: a specific cytosolic binding protein for cyclosporin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from alpha-factor arrest in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.36.20997

21 January 2018

Identifiers

DOI

10.1074/JBC.270.36.20997

1 reference

20 May 2018

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20 May 2018