(Q53915447)

22 May 2018

title

Identification of Selective Inhibitors of NAD+-dependent Deacetylases Using Phenotypic Screens in Yeast (English)

1 reference

https://api.crossref.org/works/10.1074/JBC.M308966200

19 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M308966200

19 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M308966200

19 March 2024

author name string

Maki Hirao

1

1 reference

22 May 2018

Jeffrey Posakony

2

1 reference

22 May 2018

Melisa Nelson

3

1 reference

22 May 2018

Henning Hruby

4

1 reference

22 May 2018

Manfred Jung

5

1 reference

22 May 2018

Antonio Bedalov

7

1 reference

22 May 2018

Julian A. Simon

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14534292

19 March 2024

language of work or name

English

0 references

publication date

8 October 2003

1 reference

22 May 2018

full work available at URL

http://www.jbc.org/content/278/52/52773.full.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14534292

https://api.elsevier.com/content/article/PII:S0021925820752907?httpAccept=text/xml

19 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M308966200

https://api.elsevier.com/content/article/PII:S0021925820752907?httpAccept=text/plain

19 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M308966200

https://syndication.highwire.org/content/doi/10.1074/jbc.M308966200

19 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M308966200

Journal of Biological Chemistry

19 March 2024

published in

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22 May 2018

volume

278

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22 May 2018

issue

52

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22 May 2018

page(s)

52773-52782

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22 May 2018

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability

cites work

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Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

21 January 2018

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308966200

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

21 January 2018

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A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

21 January 2018

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Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose

21 January 2018

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Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions

21 January 2018

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Structural identification of 2'- and 3'-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta -NAD+-dependent histone/protein deacetylases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308966200

Structural basis for the NAD-dependent deacetylase mechanism of Sir2

21 January 2018

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Transcriptional silencing in yeast is associated with reduced nucleosome acetylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308966200

Negative control of p53 by Sir2alpha promotes cell survival under stress

21 January 2018

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

21 January 2018

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Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

21 January 2018

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Acetylation inactivates the transcriptional repressor BCL6.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308966200

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308966200

Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine

21 January 2018

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The establishment, inheritance, and function of silenced chromatin in Saccharomyces cerevisiae

21 January 2018

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Conversion of a gene-specific repressor to a regional silencer

21 January 2018

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A novel form of transcriptional silencing by Sum1-1 requires Hst1 and the origin recognition complex

21 January 2018

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Enzymatic activities of Sir2 and chromatin silencing

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308966200

Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae

21 January 2018

1 reference

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Rfm1, a novel tethering factor required to recruit the Hst1 histone deacetylase for repression of middle sporulation genes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308966200

NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae

21 January 2018

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A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast

21 January 2018

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Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

21 January 2018

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Genetic selection of peptide inhibitors of biological pathways.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308966200

Functional discovery via a compendium of expression profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308966200

Genomewide studies of histone deacetylase function in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308966200

Identification of a small molecule inhibitor of Sir2p

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308966200

Structure of the histone deacetylase SIRT2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308966200

SWISS-MODEL: An automated protein homology-modeling server

21 January 2018

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XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density

21 January 2018

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Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308966200

Ras-Raf interaction: two-hybrid analysis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308966200

SIR2 family of NAD(+)-dependent protein deacetylases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308966200

Crystal structure of a SIR2 homolog-NAD complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308966200

Structure of a Sir2 enzyme bound to an acetylated p53 peptide

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308966200

Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308966200

The specificities of protein kinase inhibitors: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308966200

Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308966200

Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308966200

Role of NAD(+) in the deacetylase activity of the SIR2-like proteins

21 January 2018

7

1 reference

https://api.crossref.org/works/10.1074/JBC.M308966200

Drug target validation and identification of secondary drug target effects using DNA microarrays

19 March 2024

28

1 reference

https://api.crossref.org/works/10.1074/JBC.M308966200

Action of a RAP1 carboxy-terminal silencing domain reveals an underlying competition between HMR and telomeres in yeast

19 March 2024

44

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https://api.crossref.org/works/10.1074/JBC.M308966200

19 March 2024

Identifiers

1 reference

22 May 2018

1 reference

22 May 2018