(Q53933756)

English

A novel analysis of concentration-dependence of partial agonism Ring-demethylation of bupranolol results in a high affinity partial agonist (K 105) for myocardial and tracheal beta-adrenoceptors.

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

22 May 2018

http://europepmc.org/abstract/MED/6289139

A novel analysis of concentration-dependence of partial agonism Ring-demethylation of bupranolol results in a high affinity partial agonist (K 105) for myocardial and tracheal beta-adrenoceptors. (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 May 2018

http://europepmc.org/abstract/MED/6289139

author name string

H Lemoine

1

1 reference

Europe PubMed Central

PubMed publication ID

22 May 2018

http://europepmc.org/abstract/MED/6289139

A J Kaumann

2

1 reference

Europe PubMed Central

PubMed publication ID

22 May 2018

http://europepmc.org/abstract/MED/6289139

publication date

1 August 1982

1 reference

Europe PubMed Central

PubMed publication ID

22 May 2018

http://europepmc.org/abstract/MED/6289139

Naunyn-Schmiedeberg's Archives of Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

22 May 2018

http://europepmc.org/abstract/MED/6289139

320

1 reference

Europe PubMed Central

PubMed publication ID

22 May 2018

http://europepmc.org/abstract/MED/6289139

2

1 reference

Europe PubMed Central

PubMed publication ID

22 May 2018

http://europepmc.org/abstract/MED/6289139

130-144

1 reference

Europe PubMed Central

PubMed publication ID

22 May 2018

http://europepmc.org/abstract/MED/6289139

https://scigraph.springernature.com/pub.10.1007/bf00506313

0 references

beta-Adrenoceptor blocking agents as partial agonists in isolated heart muscle: dissociation of stimulation and blockade

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3H-(?)-Bupranolol, a new ?-adrenoceptor radioligand: Characterization of its binding to kitten heart ?-adrenoceptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iodohydroxybenzylpindolol: preparation, purification, localization of its iodine to the indole ring, and characterization as a partial agonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potentiation of the effects of isoprenaline and noradrenaline by hydrocortisone in cat heart muscle.

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In kitten ventricular myocardium, the inotropic potency of an agonist is determined by both its intrinsic activity for the adenylyl cyclase and its affinity for the beta-adrenoceptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apparent equilibrium constant between β-adrenoceptors and a competitive antagonist on a cultured pacemaker cell of mammalian heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein measurement with the Folin phenol reagent

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of myocardial ?-adrenoceptors by the nitrogen-free low affinity ligand 3?,4?-dihydroxy-?-methylpropiophenone (U-0521)

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Are the pA2 values of selective beta-adrenoceptor antagonists valid when obtained on guinea-pig tracheal preparations contracted with carbachol?

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fourth gaddum memorial lecture, school of pharmacy, university of london, january 1973.

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relaxation of heart muscle by catecholamines and by dibutyryl cyclic adenosine 3',5'-monophosphate. Similarity of beta-adrenoceptors mediating contractile and relaxant effects of catecholamines in kitten pipillary muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blocking of inhibitory adrenergic receptors by a dichloro analog of isoproterenol

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A modification of receptor theory

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative assessment of?-adrenoceptor blocking agents as simple competitive antagonists in isolated heart muscle: Similarity of inotropic and chronotropic blocking potencies against isoproterenol

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The nature of the adrenergic receptors of the trachea of the guinea-pig

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Desensitization of kitten atria to chronotropic, inotropic and adenylyl cyclase stimulating effects of (-)isoprenaline

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The dual action of oxyfedrine on cardiac contractility

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparison of the influence of N-isopropyl and N-tert butyl substituents on the affinity of ligands for sinoatrial ?-adrenoceptors in rat atria and ?-adrenoceptors coupled to the adenylyl cyclase in kitten ventricle

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The potentiation of the responses to noradrenaline and isoprenaline of the guinea-pig isolated tracheal chain preparation by desipramine, cocaine, phentolamine, phenoxybenzamine, guanethidine, metanephrine and cooling

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The importance of choice of agonist in studies designed to predict ? 2:? 1 adrenoceptor selectivity of antagonists from pA2 values on guinea-pig trachea and atria

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological characterization of receptors: its relation to radioligand-binding studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-receptor blocking and cardiodepressant actions of 2-nitrilophenoxypropanolamines

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Affinities of catecholamines for extraneuronal uptake in smooth muscle cells in trachealis muscle of guinea-pig

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive chronotropic effect of increasing right atrial pressure in the isolated mammalian heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the statistics of drug-receptor constants for partial agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adrenergic receptors in heart muscle: relations among factors influencing the sensitivity of the cat papillary muscle to catecholamines

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that (+)-bupranolol interacts directly with myocardial beta-adrenoceptors. Control of optical purity with differential thermal analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On spare ?-adrenoceptors for inotropic effects of catecholamines in kitten ventricle

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An uptake of radioactivity from (plus or minus)-3H-isoprenaline and its inhibition by drugs which potentiate the responses to (minus)-isoprenaline in the guinea-pig isolated trachea

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Convenient apparatus for recording contractions of isolated heart muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on receptor-mediated activation of adenylyl cyclases. IV. Characteristics of the adrenergic receptor coupled to myocardial adenylyl cyclase: stereospecificity for ligands and determination of apparent affinity constants for beta-blockers

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adrenergic receptors in the guinea-pig trachea

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of cocaine on the pacemaker of isolated guinea-pig atria

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of N-alkyl substitution on antagonism at 1 - and 2 -receptor sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulant and depressant effects of beta-adrenoceptor blocking agents on isolated heart muscle. A positive inotropic effect not mediated through andrenoceptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Some quantitative uses of drug antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On equilibrium dissociation constants for complexes of drug-receptor subtypes. Selective and non-selective interactions of partial agonists with two plausible beta-adrenoceptor subtypes mediating positive chronotropic effects of (-)-isoprenaline in

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The interaction of cocaine and propranolol with catecholamines on guinea pig trachea

1 reference

https://pubmed.ncbi.nlm.nih.gov/6289139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF00506313

1 reference

Europe PubMed Central

PubMed publication ID

22 May 2018

http://europepmc.org/abstract/MED/6289139

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 May 2018

http://europepmc.org/abstract/MED/6289139

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