(Q53946261)

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Free radical intermediates of phenytoin and related teratogens. Prostaglandin H synthase-catalyzed bioactivation, electron paramagnetic resonance spectrometry, and photochemical product analysis.

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scholarly article

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Europe PubMed Central

22 May 2018

http://europepmc.org/abstract/MED/9737965

Free radical intermediates of phenytoin and related teratogens. Prostaglandin H synthase-catalyzed bioactivation, electron paramagnetic resonance spectrometry, and photochemical product analysis. (English)

1 reference

Europe PubMed Central

22 May 2018

http://europepmc.org/abstract/MED/9737965

1 reference

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Parman T

1

1 reference

Europe PubMed Central

22 May 2018

http://europepmc.org/abstract/MED/9737965

Chen G

2

1 reference

Europe PubMed Central

22 May 2018

http://europepmc.org/abstract/MED/9737965

Wells PG

3

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Europe PubMed Central

22 May 2018

http://europepmc.org/abstract/MED/9737965

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1 September 1998

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Europe PubMed Central

22 May 2018

http://europepmc.org/abstract/MED/9737965

Journal of Biological Chemistry

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Europe PubMed Central

22 May 2018

http://europepmc.org/abstract/MED/9737965

273

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Europe PubMed Central

22 May 2018

http://europepmc.org/abstract/MED/9737965

25079-25088

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Europe PubMed Central

22 May 2018

http://europepmc.org/abstract/MED/9737965

39

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Europe PubMed Central

22 May 2018

http://europepmc.org/abstract/MED/9737965

The embryotoxicity of phenytoin: an update on possible mechanisms

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Oxidative damage in chemical teratogenesis

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Interaction of lipid peroxidation products with DNA. A review

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PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH.

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Evidence for embryonic prostaglandin H synthase-catalyzed bioactivation and reactive oxygen species-mediated oxidation of cellular macromolecules in phenytoin and benzo[a]pyrene teratogenesis

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Evidence for embryonic peroxidase-catalyzed bioactivation and glutathione-dependent cytoprotection in phenytoin teratogenicity: modulation by eicosatetraynoic acid and buthionine sulfoximine in murine embryo culture

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Effects of antioxidants on cyclooxygenase and lipoxygenase activities in intact human platelets: comparison with indomethacin and ETYA

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Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice

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DNA oxidation as a potential molecular mechanism mediating drug-induced birth defects: phenytoin and structurally related teratogens initiate the formation of 8-hydroxy-2'-deoxyguanosine in vitro and in vivo in murine maternal hepatic and embryonic

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10.1074/JBC.273.39.25079

1 reference

Europe PubMed Central

22 May 2018

http://europepmc.org/abstract/MED/9737965

1 reference

Europe PubMed Central

22 May 2018

http://europepmc.org/abstract/MED/9737965

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