(Q54031813)

23 May 2018

title

The apoptotic v-cyclin-CDK6 complex phosphorylates and inactivates Bcl-2. (English)

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23 May 2018

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6

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23 May 2018

Päivi M Ojala

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ORCID Public Data File 2021

Stanley J. Korsmeyer

5

object named as

Korsmeyer SJ

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23 May 2018

author name string

Ojala PM

1

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23 May 2018

Yamamoto K

2

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23 May 2018

Castaños-Vélez E

3

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23 May 2018

Biberfeld P

4

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23 May 2018

publication date

1 November 2000

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23 May 2018

published in

Nature Cell Biology

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23 May 2018

volume

2

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23 May 2018

page(s)

819-825

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23 May 2018

issue

11

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23 May 2018

https://scigraph.springernature.com/pub.10.1038/35041064

exact match

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cites work

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Kaposi's sarcoma-associated herpesvirus encodes a functional cyclin.

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Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins.

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Degradation of p27(Kip) cdk inhibitor triggered by Kaposi's sarcoma virus cyclin-cdk6 complex

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Modulation of p27(Kip1) levels by the cyclin encoded by Kaposi's sarcoma-associated herpesvirus

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Distinct biology of Kaposi's sarcoma-associated herpesvirus from primary lesions and body cavity lymphomas

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Proliferation and apoptosis in the evolution of endemic and acquired immunodeficiency syndrome-related Kaposi's sarcoma

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Cyclin D1 is an essential mediator of apoptotic neuronal cell death.

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Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases

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A link between cell cycle and cell death: Bax and Bcl-2 modulate Cdk2 activation during thymocyte apoptosis.

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7 January 2021

A novel apoptotic cascade mediated by CDK4 in rat pheochromocytoma PC12 cells

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7 January 2021

A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak

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7 January 2021

Kaposi's sarcoma-associated herpesvirus encodes a functional Bcl-2 homologue

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7 January 2021

BCL-2 family members and the mitochondria in apoptosis

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The Bcl-2 protein family: arbiters of cell survival

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7 January 2021

Inactivation of Bcl-2 by phosphorylation

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7 January 2021

Interleukin-3 induces the phosphorylation of a distinct fraction of bcl-2.

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7 January 2021

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

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7 January 2021

Bcl-2 phosphorylation required for anti-apoptosis function

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7 January 2021

A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis

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7 January 2021

Association of insulin receptor substrate proteins with Bcl-2 and their effects on its phosphorylation and antiapoptotic function

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7 January 2021

Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1.

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Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase

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Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis.

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7 January 2021

Mitotic phosphorylation of Bcl-2 during normal cell cycle progression and Taxol-induced growth arrest

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Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells

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Identification of a novel regulatory domain in Bcl-X(L) and Bcl-2.

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Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis

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Identification and characterization of human herpesvirus-8 lytic cycle-associated ORF 59 protein and the encoding cDNA by monoclonal antibody

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Participation of cyclin A in Myc-induced apoptosis.

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Viral interference with apoptosis

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7 January 2021

Apoptosis mediated by HIV protease is preceded by cleavage of Bcl-2

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Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2.

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Human immunodeficiency virus induces a dual regulation of Bcl-2, resulting in persistent infection of CD4(+) T- or monocytic cell lines

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7 January 2021

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

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7 January 2021

Detection of the human herpesvirus 8-encoded cyclin protein in primary effusion lymphoma-derived cell lines

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7 January 2021

Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation.

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D-type cyclin-dependent kinase activity in mammalian cells

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7 January 2021

Identifiers

DOI

10.1038/35041064

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23 May 2018

PubMed ID

11056537

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23 May 2018