(Q54102655)

24 May 2018

title

Mechanism of transcriptional repression of E2F by the retinoblastoma tumor suppressor protein. (English)

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24 May 2018

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Ross JF

1

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24 May 2018

Liu X

series ordinal

2

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24 May 2018

Dynlacht BD

series ordinal

3

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24 May 2018

publication date

1 February 1999

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24 May 2018

published in

Molecular Cell

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24 May 2018

volume

3

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24 May 2018

issue

2

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24 May 2018

page(s)

195-205

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24 May 2018

The retinoblastoma susceptibility gene product represses transcription when directly bound to the promoter

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Retinoblastoma protein recruits histone deacetylase to repress transcription

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Direct transcriptional repression by pRB and its reversal by specific cyclins

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The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

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Five intermediate complexes in transcription initiation by RNA polymerase II

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The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila

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Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

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7 January 2021

Assembly of the isomerized TFIIA--TFIID--TATA ternary complex is necessary and sufficient for gene activation

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7 January 2021

A role for a bent DNA structure in E2F-mediated transcription activation

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7 January 2021

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

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7 January 2021

Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

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7 January 2021

Regulation of transcription by proteins that control the cell cycle

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7 January 2021

Differential regulation of E2F transactivation by cyclin/cdk2 complexes

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7 January 2021

Specific regulation of E2F family members by cyclin-dependent kinases

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7 January 2021

The regulation of E2F by pRB-family proteins

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Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes

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E2F-1 functions in mice to promote apoptosis and suppress proliferation

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7 January 2021

Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes

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7 January 2021

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein

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7 January 2021

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation

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7 January 2021

Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression

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The requirement for the basal transcription factor IIE is determined by the helical stability of promoter DNA.

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1.9 A resolution refined structure of TBP recognizing the minor groove of TATAAAAG

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A class of activation domains interacts directly with TFIIA and stimulates TFIIA-TFIID-promoter complex assembly

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7 January 2021

p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation

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7 January 2021

Mechanistic analysis of RNA polymerase III regulation by the retinoblastoma protein

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7 January 2021

E2F3 activity is regulated during the cell cycle and is required for the induction of S phase.

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7 January 2021

Immunoaffinity purification of the human multisubunit transcription factor IIH

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7 January 2021

A mechanism for TAFs in transcriptional activation: activation domain enhancement of TFIID-TFIIA--promoter DNA complex formation

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7 January 2021

The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T.

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7 January 2021

Rb interacts with histone deacetylase to repress transcription

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7 January 2021

Retinoblastoma protein represses transcription by recruiting a histone deacetylase

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7 January 2021

Purification of human RNA polymerase II and general transcription factors

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7 January 2021

Factors involved in specific transcription by mammalian RNA polymerase II: role of transcription factors IIA, IID, and IIB during formation of a transcription-competent complex

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7 January 2021

Activation of class II gene transcription by regulatory factors is potentiated by a novel activity

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7 January 2021

The retinoblastoma gene family: cousins with overlapping interests

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7 January 2021

The mammalian transcriptional repressor RBP (CBF1) targets TFIID and TFIIA to prevent activated transcription

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7 January 2021

Molecular cloning of the small (gamma) subunit of human TFIIA reveals functions critical for activated transcription

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7 January 2021

Promoter specificity of basal transcription factors

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7 January 2021

Structure and functional properties of human general transcription factor IIE

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7 January 2021

Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development

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7 January 2021

Transcriptional control of the cell cycle

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7 January 2021

Factors involved in specific transcription by human RNA polymerase II: analysis by a rapid and quantitative in vitro assay

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7 January 2021

A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites

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7 January 2021

The retinoblastoma-susceptibility gene product binds directly to the human TATA-binding protein-associated factor TAFII250

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7 January 2021

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7 January 2021

Topoisomerase I enhances TFIID-TFIIA complex assembly during activation of transcription

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7 January 2021

Physical Analysis of Transcription Preinitiation Complex Assembly on a Class II Gene Promoter

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7 January 2021

Binding of TAFs to core elements directs promoter selectivity by RNA polymerase II

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7 January 2021

Mechanism of repression of RNA polymerase I transcription by the retinoblastoma protein

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7 January 2021

The retinoblastoma protein and cell cycle control

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7 January 2021

Mechanism of active transcriptional repression by the retinoblastoma protein

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980310-X

7 January 2021

Multiple members of the E2F transcription factor family are the products of oncogenes

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980310-X

7 January 2021

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice

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7 January 2021

Tumor induction and tissue atrophy in mice lacking E2F-1

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980310-X

7 January 2021

Holo-TFIID supports transcriptional stimulation by diverse activators and from a TATA-less promoter

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980310-X

7 January 2021

10.1016/S1097-2765(00)80310-X

Identifiers

DOI

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24 May 2018

1 reference

24 May 2018