(Q54228570)

26 May 2018

title

The microRNA Machinery. (English)

1 reference

26 May 2018

1 reference

Thomas C Roberts

1

1 reference

26 May 2018

language of work or name

English

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publication date

1 January 2015

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26 May 2018

Advances in Experimental Medicine and Biology

published in

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26 May 2018

volume

887

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26 May 2018

page(s)

15-30

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26 May 2018

Post-transcriptional gene silencing by siRNAs and miRNAs

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MicroRNA genes are transcribed by RNA polymerase II

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Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs

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Processing of intronic microRNAs

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Identification of novel genes coding for small expressed RNAs

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The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease

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MicroRNA maturation: stepwise processing and subcellular localization

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The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation

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Specificity of microRNA target selection in translational repression

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Patterns of flanking sequence conservation and a characteristic upstream motif for microRNA gene identification

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Mammalian microRNAs predominantly act to decrease target mRNA levels

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Human RISC couples microRNA biogenesis and posttranscriptional gene silencing

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The Microprocessor complex mediates the genesis of microRNAs

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Human RNase III is a 160-kDa protein involved in preribosomal RNA processing

21 January 2018

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The nuclear RNase III Drosha initiates microRNA processing

21 January 2018

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Short interfering RNA-mediated knockdown of drosha and pasha in undifferentiated Meloidogyne incognita eggs leads to irregular growth and embryonic lethality.

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The RNase III enzyme DROSHA is essential for microRNA production and spermatogenesis

21 January 2018

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Role for a bidentate ribonuclease in the initiation step of RNA interference

21 January 2018

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The Drosha-DGCR8 complex in primary microRNA processing

21 January 2018

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DiGeorge syndrome: part of CATCH 22.

21 January 2018

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Molecular cloning and expression analysis of a novel gene DGCR8 located in the DiGeorge syndrome chromosomal region

21 January 2018

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Processing of primary microRNAs by the Microprocessor complex

21 January 2018

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The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis

21 January 2018

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Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha

21 January 2018

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Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex

21 January 2018

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Solution structure of the Drosha double-stranded RNA-binding domain

21 January 2018

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Crystal structure of human DGCR8 core

21 January 2018

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Structure of the dimerization domain of DiGeorge Critical Region 8

21 January 2018

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Heme is involved in microRNA processing

21 January 2018

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Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins

21 January 2018

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Nuclear export of microRNA precursors

21 January 2018

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Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

21 January 2018

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Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs

21 January 2018

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Exportin-5 mediates nuclear export of minihelix-containing RNAs

21 January 2018

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Terminal minihelix, a novel RNA motif that directs polymerase III transcripts to the cell cytoplasm. Terminal minihelix and RNA export

21 January 2018

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Adenovirus VA1 noncoding RNA can inhibit small interfering RNA and MicroRNA biogenesis

21 January 2018

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Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport

21 January 2018

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Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1

21 January 2018

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Structural requirements for pre-microRNA binding and nuclear export by Exportin 5.

21 January 2018

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A high-resolution structure of the pre-microRNA nuclear export machinery

21 January 2018

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Ribonuclease activity and RNA binding of recombinant human Dicer

21 January 2018

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Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

21 January 2018

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Complexity of murine cardiomyocyte miRNA biogenesis, sequence variant expression and function

21 January 2018

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Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing

21 January 2018

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A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

21 January 2018

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Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

21 January 2018

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Dicer is essential for mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Stem cell division is regulated by the microRNA pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Single processing center models for human Dicer and bacterial RNase III

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Structural basis for double-stranded RNA processing by Dicer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Human let-7 stem-loop precursors harbor features of RNase III cleavage products

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Structural determinants of RNA recognition and cleavage by Dicer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Structure of the human Dicer-TRBP complex by electron microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Structural insights into RNA processing by the human RISC-loading complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

The molecular architecture of human Dicer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Dicer recognizes the 5' end of RNA for efficient and accurate processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Argonaute2, a link between genetic and biochemical analyses of RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Functional siRNAs and miRNAs Exhibit Strand Bias

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Asymmetry in the assembly of the RNAi enzyme complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

let-7 regulates Dicer expression and constitutes a negative feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Most mammalian mRNAs are conserved targets of microRNAs

21 January 2018

1 reference

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A microRNA in a multiple-turnover RNAi enzyme complex

21 January 2018

1 reference

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MicroRNA-directed cleavage of HOXB8 mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Relief of microRNA-mediated translational repression in human cells subjected to stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Repression of protein synthesis by miRNAs: how many mechanisms?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

21 January 2018

1 reference

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MicroRNAs: genomics, biogenesis, mechanism, and function

21 January 2018

1 reference

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Combinatorial microRNA target predictions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Argonaute2 is the catalytic engine of mammalian RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

The evolutionary journey of Argonaute proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Purified Argonaute2 and an siRNA form recombinant human RISC

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Molecular dissection of human Argonaute proteins by DNA shuffling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Argonaute2 is essential for mammalian gastrulation and proper mesoderm formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

One Argonaute family member, Eif2c2 (Ago2), is essential for development and appears not to be involved in DNA methylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

The Crystal Structure of Human Argonaute2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

The Structure of Human Argonaute-2 in Complex with miR-20a

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

A role for the P-body component GW182 in microRNA function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-22380-3_2

10.1007/978-3-319-22380-3_2

21 January 2018

Identifiers

DOI

1 reference

26 May 2018

1 reference

26 May 2018