(Q54294766)

27 May 2018

title

Atomistic insights into the lung cancer-associated L755P mutation in HER2 resistance to lapatinib: a molecular dynamics study. (English)

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27 May 2018

author name string

Bei Yang

series ordinal

1

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27 May 2018

Haiping Zhang

series ordinal

2

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27 May 2018

Hao Wang

series ordinal

3

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27 May 2018

publication date

27 January 2015

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27 May 2018

Journal of Molecular Modeling

published in

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27 May 2018

volume

21

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27 May 2018

issue

2

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27 May 2018

page(s)

24

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27 May 2018

https://scigraph.springernature.com/pub.10.1007/s00894-015-2580-x

exact match

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cites work

Nuclear signaling by receptor tyrosine kinases: the first robin of spring

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

The ErbB/HER family of protein-tyrosine kinases and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

All EGF(ErbB) receptors have preformed homo- and heterodimeric structures in living cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Targeting the EGFR signaling pathway in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2-amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Comparison of the EGFR resistance mutation profiles generated by EGFR-targeted tyrosine kinase inhibitors and the impact of drug combinations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Acquired resistance to epidermal growth factor receptor kinase inhibitors associated with a novel T854A mutation in a patient with EGFR-mutant lung adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Impact of common epidermal growth factor receptor and HER2 variants on receptor activity and inhibition by lapatinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Lung cancer: intragenic ERBB2 kinase mutations in tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Modeling of loops in protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Insights into the role of magnesium triad in myo-inositol monophosphatase: metal mechanism, substrate binding, and lithium therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

The structural basis of ATP as an allosteric modulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Development and testing of a general amber force field

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Comparison of simple potential functions for simulating liquid water

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

A water-based mechanism of specificity and resistance for lapatinib with ErbB family kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

In silico design: extended molecular dynamic simulations of a new series of dually acting inhibitors against EGFR and HER2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Assessing the performance of MM/PBSA and MM/GBSA methods. 4. Accuracies of MM/PBSA and MM/GBSA methodologies evaluated by various simulation protocols using PDBbind data set.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Clustering Molecular Dynamics Trajectories: 1. Characterizing the Performance of Different Clustering Algorithms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Ten-nanosecond molecular dynamics simulation of the motions of the horse liver alcohol dehydrogenase.PhCH2O- complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Structural basis of valmerins as dual inhibitors of GSK3β/CDK5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

αC helix displacement as a general approach for allosteric modulation of protein kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Harnessing allostery: a novel approach to drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Activation loop phosphorylation and catalysis in protein kinases: is there functional evidence for the autoinhibitor model?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Regulation of protein kinases; controlling activity through activation segment conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Mechanism of kinase inactivation and nonbinding of FRATide to GSK3β due to K85M mutation: molecular dynamics simulation and normal mode analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Beyond chemotherapy: targeted therapies in ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

P-loop conformation governed crizotinib resistance in G2032R-mutated ROS1 tyrosine kinase: clues from free energy landscape

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Dual-inhibitors of STAT5 and STAT3: studies from molecular docking and molecular dynamics simulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Recent computational advances in the identification of allosteric sites in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Molecular simulation-based structural prediction of protein complexes in mass spectrometry: the human insulin dimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Phosphorylation of the retinoic acid receptor alpha induces a mechanical allosteric regulation and changes in internal dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Molecular dynamics reveal binding mode of glutathionylspermidine by trypanothione synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Exploring protein native states and large-scale conformational changes with a modified generalized born model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Ligand induced change of β2adrenergic receptor from active to inactive conformation and its implication for the closed/open state of the water channel: insight from molecular dynamics simulation, free energy calculation and Markov state model analys

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00894-015-2580-X

Targeting tyrosine kinases in cancer: the second wave

21 January 2018

1 reference

12 December 2020

CancerDR: cancer drug resistance database.

1 reference

12 December 2020

Use of erlotinib or gefitinib as initial therapy in advanced NSCLC.

1 reference

12 December 2020

T790M and acquired resistance of EGFR TKI: a literature review of clinical reports

1 reference

12 December 2020

10.1007/S00894-015-2580-X

Identifiers

DOI

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27 May 2018

1 reference

27 May 2018