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The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
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scholarly article
1 reference
stated in
PubMed
PubMed ID
18227510
retrieved
13 November 2016
title
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
(English)
1 reference
stated in
PubMed
PubMed ID
18227510
retrieved
13 November 2016
author
Heidi Greulich
series ordinal
5
0 references
Kwok Kin Wong
series ordinal
6
object named as
Kwok-Kin Wong
0 references
Matthew Meyerson
series ordinal
7
object named as
Matthew Meyerson
0 references
author name string
Cai-Hong Yun
series ordinal
1
0 references
Kristen E Mengwasser
series ordinal
2
0 references
Angela V Toms
series ordinal
3
0 references
Michele S Woo
series ordinal
4
0 references
Michael J Eck
series ordinal
8
0 references
language of work or name
English
0 references
publication date
12 February 2008
0 references
published in
Proceedings of the National Academy of Sciences of the United States of America
0 references
volume
105
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page(s)
2070-5
0 references
issue
6
0 references
cites work
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
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PubMed Central
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Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants
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Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
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EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
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PubMed Central
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7 April 2017
Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors
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Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity
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PubMed Central
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EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination
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Crossref
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22 April 2017
Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors
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PubMed Central
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A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells
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Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
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Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
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ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism
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Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation
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PubMed Central
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Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy
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Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib
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28 September 2017
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PubMed Central
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PubMed Central
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28 September 2017
Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2538882
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28 September 2017
Optimization of 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity.
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PubMed Central
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28 September 2017
Mutations and addiction to EGFR: the Achilles 'heal' of lung cancers?
1 reference
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PubMed Central
reference URL
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28 September 2017
Amino acid substitutions sufficient to convert the nontransforming p60c-src protein to a transforming protein
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2538882
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28 September 2017
Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2538882
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30 May 2018
Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1073%2FPNAS.0709662105
retrieved
21 January 2018
Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1073%2FPNAS.0709662105
retrieved
21 January 2018
Processing of X-ray diffraction data collected in oscillation mode
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1073%2FPNAS.0709662105
retrieved
21 January 2018
Allele-dependent variation in the relative cellular potency of distinct EGFR inhibitors
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18227510
retrieved
12 December 2020
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inferred from PubMed ID database lookup
Identifiers
DOI
10.1073/PNAS.0709662105
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
63158
ADS bibcode
2008PNAS..105.2070Y
0 references
OpenCitations bibliographic resource ID
63158
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
63158
PMCID
2538882
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
63158
PubMed ID
18227510
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
63158
ResearchGate publication ID
5623410
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