(Q40070799)

17 September 2017

title

ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism (English)

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17 September 2017

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14

Roman Sakowicz

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17 September 2017

Lusong Luo

1

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17 September 2017

Cynthia A Parrish

2

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17 September 2017

Neysa Nevins

3

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17 September 2017

Dean E McNulty

4

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17 September 2017

Amita M Chaudhari

5

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17 September 2017

Jeffery D Carson

6

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17 September 2017

Valery Sudakin

7

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17 September 2017

Antony N Shaw

8

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17 September 2017

Ruth Lehr

9

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17 September 2017

Huizhen Zhao

10

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17 September 2017

Sharon Sweitzer

11

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17 September 2017

Latesh Lad

12

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17 September 2017

Kenneth W Wood

13

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17 September 2017

Roland S Annan

15

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17 September 2017

Pearl S Huang

16

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17 September 2017

Jeffrey R Jackson

17

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17 September 2017

Dashyant Dhanak

18

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17 September 2017

Robert A Copeland

19

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17 September 2017

Kurt R Auger

20

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17 September 2017

publication date

7 October 2007

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17 September 2017

published in

Nature Chemical Biology

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17 September 2017

volume

3

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17 September 2017

issue

11

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17 September 2017

page(s)

722-726

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The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks

17 September 2017

cites work

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

Antitumor activity of a kinesin inhibitor

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

Mitotic kinesins: prospects for antimitotic drug discovery.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

Targeted anti-mitotic therapies: can we improve on tubulin agents?

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

Monastrol inhibition of the mitotic kinesin Eg5.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

Mechanism of inhibition of human KSP by monastrol: insights from kinetic analysis and the effect of ionic strength on KSP inhibition

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

Inhibition of a mitotic motor protein: where, how, and conformational consequences

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

Novel ATP-competitive kinesin spindle protein inhibitors

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

A method for determining intracellular concentrations of enzyme substrates from a combination of competitive inhibition and mutagenesis studies

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

Resistance to imatinib: mechanisms and management

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

The emergence of resistance to targeted cancer therapeutics

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

KIF1A alternately uses two loops to bind microtubules

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

Single-molecule observations of neck linker conformational changes in the kinesin motor protein.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

A structural change in the kinesin motor protein that drives motility

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

A new structural state of myosin.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

Resistance to non-nucleoside inhibitors of HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

Defining a molecular mechanism of synergy between nucleoside and nonnucleoside AIDS drugs.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

Drug combinations and effect parameters of zidovudine, stavudine, and nevirapine in standardized drug-sensitive and resistant HIV type 1 strains

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.34

7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO.2007.34

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17 September 2017

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