(Q36717905)

15 August 2017

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title

Targeted anti-mitotic therapies: can we improve on tubulin agents? (English)

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15 August 2017

Jeffrey R Jackson

1

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15 August 2017

Denis R Patrick

series ordinal

2

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15 August 2017

Mohammed M Dar

series ordinal

3

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15 August 2017

Pearl S Huang

series ordinal

4

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15 August 2017

language of work or name

English

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publication date

1 February 2007

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15 August 2017

Nature Reviews Cancer

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15 August 2017

7

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15 August 2017

107-117

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15 August 2017

2

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https://scigraph.springernature.com/pub.10.1038/nrc2049

15 August 2017

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cites work

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CENP-E function at kinetochores is essential for chromosome alignment.

31 March 2020

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CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment

31 March 2020

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CENP-E as an essential component of the mitotic checkpoint in vitro.

31 March 2020

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Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage

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Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells.

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Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells.

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31 March 2020

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Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

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The bimC family of kinesins: essential bipolar mitotic motors driving centrosome separation

31 March 2020

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Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

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Antitumor activity of a kinesin inhibitor

31 March 2020

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Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5.

31 March 2020

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Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5.

31 March 2020

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Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5.

31 March 2020

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Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP.

31 March 2020

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Inhibition of a mitotic motor protein: where, how, and conformational consequences

31 March 2020

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Crystal structure of the motor domain of the human kinetochore protein CENP-E

31 March 2020

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Interaction of Skp1 with CENP-E at the midbody is essential for cytokinesis

31 March 2020

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The microtubule-dependent motor centromere-associated protein E (CENP-E) is an integral component of kinetochore corona fibers that link centromeres to spindle microtubules.

31 March 2020

1 reference

Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC

31 March 2020

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Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1.

31 March 2020

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CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells

31 March 2020

1 reference

CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint

31 March 2020

1 reference

Chromosomes can congress to the metaphase plate before biorientation

31 March 2020

1 reference

Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E

31 March 2020

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Mitotic mechanics: the auroras come into view

31 March 2020

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Aurora-A - a guardian of poles

31 March 2020

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Aurora A and B kinases as targets for cancer: will they be selective for tumors?

31 March 2020

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Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules.

31 March 2020

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Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans

31 March 2020

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Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation

31 March 2020

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The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

31 March 2020

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The Aurora kinase inhibitor VX-680 induces endoreduplication and apoptosis preferentially in cells with compromised p53-dependent postmitotic checkpoint function

31 March 2020

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Mitotic requirement for aurora A kinase is bypassed in the absence of aurora B kinase

31 March 2020

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Polo-like kinases and the orchestration of cell division

31 March 2020

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Polo-like kinases (Plks) and cancer

31 March 2020

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Polo-like kinases and oncogenesis

31 March 2020

1 reference

Roles of polo-like kinase 1 in the assembly of functional mitotic spindles

31 March 2020

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Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells

31 March 2020

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The bereavement visit in pediatric oncology.

31 March 2020

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Randomized phase III trial comparing irinotecan/cisplatin with etoposide/cisplatin in patients with previously untreated extensive-stage disease small-cell lung cancer

31 March 2020

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Phase II study of erlotinib in patients with advanced biliary cancer

31 March 2020

1 reference

PHA-680632, a novel Aurora kinase inhibitor with potent antitumoral activity.

31 March 2020

1 reference

Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer

31 March 2020

1 reference

Gene expression profiles in paraffin-embedded core biopsy tissue predict response to chemotherapy in women with locally advanced breast cancer

31 March 2020

1 reference

Prediction of individual response to platinum/paclitaxel combination using novel marker genes in ovarian cancers

31 March 2020

1 reference

Cardiac toxicity assessment in locally advanced breast cancer treated neoadjuvantly with doxorubicin/paclitaxel regimen

31 March 2020

1 reference

Sequence-dependent alteration of doxorubicin pharmacokinetics by paclitaxel in a phase I study of paclitaxel and doxorubicin in patients with metastatic breast cancer

31 March 2020

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Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells

31 March 2020

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Quantification of cellular proliferation in tumor and normal tissues of patients with breast cancer by [18F]fluorothymidine-positron emission tomography imaging: evaluation of analytical methods

31 March 2020

1 reference

Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC2049

1 reference

15 August 2017

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