(Q28255830)

4

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Jean-Luc Perfettini

object named as

Jean-Luc Perfettini

2

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René H. Medema

object named as

Rene Medema

5

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author name string

Maria Castedo

1

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Thomas Roumier

p53 deficiency and defective mitotic checkpoint in proliferating T lymphocytes increase chromosomal instability through aberrant exit from mitotic arrest

3

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language of work or name

English

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publication date

12 April 2004

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published in

Oncogene

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volume

23

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issue

16

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page(s)

2825-37

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cites work

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Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death?

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Survivin is required for stable checkpoint activation in taxol-treated HeLa cells

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Human immunodeficiency virus 1 envelope glycoprotein complex-induced apoptosis involves mammalian target of rapamycin/FKBP12-rapamycin-associated protein-mediated p53 phosphorylation

21 January 2018

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Aneuploidy and prognosis of non-small-cell lung cancer: a meta-analysis of published data

21 January 2018

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hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells

21 January 2018

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Micronuclei to detect in vivo chemotherapy damage in a p53 mutated solid tumour

21 January 2018

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Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint

21 January 2018

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Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53

21 January 2018

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Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria

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Endopolyploid cells produced after severe genotoxic damage have the potential to repair DNA double strand breaks

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Chromosome segregation and cancer: cutting through the mystery

21 January 2018

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Nuclear localization of cyclin B1 controls mitotic entry after DNA damage

21 January 2018

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

21 January 2018

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

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Centrosome amplification drives chromosomal instability in breast tumor development

21 January 2018

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Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells

21 January 2018

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A unified view of the DNA-damage checkpoint

21 January 2018

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Mitotic kinases as regulators of cell division and its checkpoints

21 January 2018

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Caspase-2 can trigger cytochrome C release and apoptosis from the nucleus.

21 January 2018

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A novel Apaf-1-independent putative caspase-2 activation complex

21 January 2018

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Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis

21 January 2018

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Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome

21 January 2018

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Determination of substrate specificity and putative substrates of Chk2 kinase

21 January 2018

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Survivin inhibition induces human neural tumor cell death through caspase-independent and -dependent pathways

21 January 2018

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Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis

21 January 2018

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Two distinct pathways leading to nuclear apoptosis

21 January 2018

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Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody

21 January 2018

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A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer

21 January 2018

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Structural basis for phosphoserine-proline recognition by group IV WW domains

21 January 2018

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Inactivation of p53 in a human ovarian cancer cell line increases the sensitivity to paclitaxel by inducing G2/M arrest and apoptosis

21 January 2018

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p53 negatively regulates cdc2 transcription via the CCAAT-binding NF-Y transcription factor

21 January 2018

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Biologists question adult stem-cell versatility

21 January 2018

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Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

21 January 2018

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7 January 2021

Cold-sensitive mutants of p34cdc2 that suppress a mitotic catastrophe phenotype in fission yeast.

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7 January 2021

IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects

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7 January 2021

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

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7 January 2021

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

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7 January 2021

Mutations of mitotic checkpoint genes in human cancers

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7 January 2021

Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe.

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7 January 2021

14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

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7 January 2021

Centrosome amplification and the development of cancer

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7 January 2021

Chemotherapy: targeting the mitochondrial cell death pathway

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7 January 2021

Tumor regression by combination antisense therapy against Plk1 and Bcl-2

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7 January 2021

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

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7 January 2021

Apoptosis control in syncytia induced by the HIV type 1-envelope glycoprotein complex: role of mitochondria and caspases.

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7 January 2021

Apoptosis and karyogamy in syncytia induced by the HIV-1-envelope glycoprotein complex

1 reference

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7 January 2021

Control of apoptotic DNA degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Organelle-specific initiation of cell death pathways

1 reference

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7 January 2021

The consequence of p53 overexpression for liver tumor development and the response of transformed murine hepatocytes to genotoxic agents.

1 reference

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7 January 2021

Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase

1 reference

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7 January 2021

Temporal relationship of CDK1 activation and mitotic arrest to cytosolic accumulation of cytochrome C and caspase-3 activity during Taxol-induced apoptosis of human AML HL-60 cells

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7 January 2021

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

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7 January 2021

Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Control of apoptosis and mitotic spindle checkpoint by survivin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Chromosome instability in human lung cancers: possible underlying mechanisms and potential consequences in the pathogenesis

1 reference

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7 January 2021

Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors

1 reference

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7 January 2021

Hyperploidy induced by drugs that inhibit formation of microtubule promotes chromosome instability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Prevention of mammalian DNA reduplication, following the release from the mitotic spindle checkpoint, requires p53 protein, but not p53-mediated transcriptional activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

A p34(cdc2) survival checkpoint in cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Centrosome multiplication accompanies a transient clustering of polyploid cells during tissue repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Nuclear localization of cyclin B1 regulates DNA damage-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Inactivation of p53 and the development of tetraploidy in the elastase-SV40 T antigen transgenic mouse pancreas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Megakaryocyte polyploidization is associated with a functional gene amplification

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Radiation-induced centrosome overduplication and multiple mitotic spindles in human tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Amplification/overexpression of a mitotic kinase gene in human bladder cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Waiting for anaphase: Mad2 and the spindle assembly checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Downregulation of human polo-like kinase activity by antisense oligonucleotides induces growth inhibition in cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

A role for mismatch repair in control of DNA ploidy following DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Molecular characterization of mitochondrial apoptosis-inducing factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Drosophila checkpoint kinase 2 couples centrosome function and spindle assembly to genomic integrity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Regulation of the G2/M transition by p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Mechanism of hyperploid cell formation induced by microtubule inhibiting drug in glioma cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Transplanted bone marrow regenerates liver by cell fusion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Induction of polyploidy and apoptosis after exposure to high concentrations of the spindle poison nocodazole

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Characterization of tumor-associated Chk2 mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Cell fusion causes confusion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

C-myc overexpression and p53 loss cooperate to promote genomic instability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021

Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207528

7 January 2021