(Q73263605)

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IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects

scientific article published on 01 November 2000

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2 November 2019

IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects (English)

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2 November 2019

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Behrend L

1

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2 November 2019

Milne DM

2

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2 November 2019

Stöter M

3

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2 November 2019

Deppert W

4

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2 November 2019

Campbell LE

5

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2 November 2019

Meek DW

6

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2 November 2019

Knippschild U

7

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2 November 2019

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1 November 2000

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2 November 2019

1 reference

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2 November 2019

19

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2 November 2019

47

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2 November 2019

5303-5313

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2 November 2019

https://scigraph.springernature.com/pub.10.1038/sj.onc.1203939

0 references

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

1 reference

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The p53 network

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Spindle assembly and the art of regulating microtubule dynamics by MAPs and Stathmin/Op18.

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Cell cycle-dependent localization of casein kinase I to mitotic spindles.

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Dynein and dynactin are localized to astral microtubules and at cortical sites in mitotic epithelial cells.

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Accessory protein regulation of microtubule dynamics throughout the cell cycle.

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Autoinhibition of casein kinase I epsilon (CKI epsilon) is relieved by protein phosphatases and limited proteolysis

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The role of workhorse protein kinases in coordinating DNA metabolism and cell growth.

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A p53-dependent mouse spindle checkpoint

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Monoclonal antibodies to mitotic cells

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Cell surface antigens of chemically induced sarcomas of the mouse. I. Murine leukemia virus-related antigens and alloantigens on cultured fibroblasts and sarcoma cells: description of a unique antigen on BALB/c Meth A sarcoma

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Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2

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Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15

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Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family

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Spontaneous polyploidization results in apoptosis in a Meth-A tumor cell line.

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Opposing motor activities are required for the organization of the mammalian mitotic spindle pole

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In vitro phosphorylation of SV40 large T antigen

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Role of COOH-terminal phosphorylation in the regulation of casein kinase I delta

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Casein kinase I: spatial organization and positioning of a multifunctional protein kinase family

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An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control

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Human p53 is phosphorylated on serines 6 and 9 in response to DNA damage-inducing agents

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HRR25, a putative protein kinase from budding yeast: association with repair of damaged DNA.

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Japan split over US aid for spy satellites

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p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs

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Casein kinase 1 is tightly associated with paired-helical filaments isolated from Alzheimer's disease brain.

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Characterization of the p53-dependent postmitotic checkpoint following spindle disruption

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Expression and function of Drosophila cyclin A during embryonic cell cycle progression.

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Crystallographic studies of casein kinase I delta toward a structural understanding of auto-inhibition

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Crystal structure of a conformation-selective casein kinase-1 inhibitor

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Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage

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Prevention of mammalian DNA reduplication, following the release from the mitotic spindle checkpoint, requires p53 protein, but not p53-mediated transcriptional activity

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Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

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