(Q54297451)

27 May 2018

title

Metastasis is driven by sequential elevation of H-ras and Smad2 levels. (English)

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2

Rosemary J Akhurst

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author name string

Martin Oft

series ordinal

1

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27 May 2018

Allan Balmain

series ordinal

3

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27 May 2018

publication date

1 July 2002

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27 May 2018

published in

Nature Cell Biology

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volume

4

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27 May 2018

page(s)

487-494

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issue

7

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https://scigraph.springernature.com/pub.10.1038/ncb807

exact match

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cites work

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7 January 2021

TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice

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TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells

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TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis

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Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

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7 January 2021

Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells

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Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm.

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A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway

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Smad2 role in mesoderm formation, left-right patterning and craniofacial development

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7 January 2021

An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct

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7 January 2021

MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

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7 January 2021

Transcriptional control by the TGF-beta/Smad signaling system

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7 January 2021

TGF-beta signaling by Smad proteins

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7 January 2021

Role of the beta3 integrin subunit in human primary melanoma progression: multifunctional activities associated with alpha(v)beta3 integrin expression

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Integration of positive and negative growth signals during ras pathway activation in vivo

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Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells

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Elevated serum levels of transforming growth factor-beta1 in patients with colorectal carcinoma: its association with tumor progression and its significant decrease after curative surgical resection

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7 January 2021

Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate

1 reference

7 January 2021

Identifiers

DOI

10.1038/NCB807

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27 May 2018

Dimensions Publication ID

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27 May 2018