(Q54314770)

English

Combine MEK inhibition with PI3K/mTOR inhibition exert inhibitory tumor growth effect on KRAS and PIK3CA mutation CRC xenografts due to reduced expression of VEGF and matrix metallopeptidase-9.

scientific article published on 19 October 2014

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

27 May 2018

http://europepmc.org/abstract/MED/25326806

Combine MEK inhibition with PI3K/mTOR inhibition exert inhibitory tumor growth effect on KRAS and PIK3CA mutation CRC xenografts due to reduced expression of VEGF and matrix metallopeptidase-9. (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 May 2018

http://europepmc.org/abstract/MED/25326806

1 reference

based on heuristic

inferred from title

colorectal carcinoma

1 reference

based on heuristic

inferred from title

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25326806%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

author name string

Jifu E

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25326806%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Junjie Xing

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25326806%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Haifeng Gong

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25326806%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Jian He

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25326806%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

publication date

19 October 2014

1 reference

Europe PubMed Central

PubMed publication ID

27 May 2018

http://europepmc.org/abstract/MED/25326806

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25326806%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

36

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25326806%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25326806%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1091-1097

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25326806%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

https://scigraph.springernature.com/pub.10.1007/s13277-014-2667-5

0 references

European cancer mortality predictions for the year 2011.

1 reference

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Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer

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Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer

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21 January 2018

PI3K pathway alterations in cancer: variations on a theme

1 reference

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21 January 2018

High frequency of mutations of the PIK3CA gene in human cancers

1 reference

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21 January 2018

Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis

1 reference

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21 January 2018

AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in precl

1 reference

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21 January 2018

The novel phosphoinositide 3-kinase-mammalian target of rapamycin inhibitor, BEZ235, circumvents erlotinib resistance of epidermal growth factor receptor mutant lung cancer cells triggered by hepatocyte growth factor.

1 reference

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21 January 2018

Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer

1 reference

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21 January 2018

Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer

1 reference

https://api.crossref.org/works/10.1007%2FS13277-014-2667-5

21 January 2018

Cancer statistics, 2009

1 reference

https://api.crossref.org/works/10.1007%2FS13277-014-2667-5

21 January 2018

The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer.

1 reference

https://api.crossref.org/works/10.1007%2FS13277-014-2667-5

21 January 2018

PI3K and MEK inhibitor combinations: examining the evidence in selected tumor types

1 reference

https://api.crossref.org/works/10.1007%2FS13277-014-2667-5

21 January 2018

BRAF mutation predicts sensitivity to MEK inhibition

1 reference

https://api.crossref.org/works/10.1007%2FS13277-014-2667-5

21 January 2018

From basic research to clinical development of MEK1/2 inhibitors for cancer therapy

1 reference

https://api.crossref.org/works/10.1007%2FS13277-014-2667-5

21 January 2018

In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models.

1 reference

https://api.crossref.org/works/10.1007%2FS13277-014-2667-5

21 January 2018

PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers

1 reference

https://api.crossref.org/works/10.1007%2FS13277-014-2667-5

21 January 2018

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

1 reference

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21 January 2018

Activation of ERK-p53 and ERK-mediated phosphorylation of Bcl-2 are involved in autophagic cell death induced by the c-Met inhibitor SU11274 in human lung cancer A549 cells

1 reference

https://api.crossref.org/works/10.1007%2FS13277-014-2667-5

21 January 2018

The prevalence of PIK3CA mutations in gastric and colon cancer.

1 reference

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21 January 2018

PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer

1 reference

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21 January 2018

Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study

1 reference

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21 January 2018

A Phase II, open-label, randomised study to assess the efficacy and safety of the MEK1/2 inhibitor AZD6244 (ARRY-142886) versus capecitabine monotherapy in patients with colorectal cancer who have failed one or two prior chemotherapeutic regimens

1 reference

https://pubmed.ncbi.nlm.nih.gov/25326806

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/25326806

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25326806

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S13277-014-2667-5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25326806%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25326806%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

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