(Q82758717)

English

A Phase II, open-label, randomised study to assess the efficacy and safety of the MEK1/2 inhibitor AZD6244 (ARRY-142886) versus capecitabine monotherapy in patients with colorectal cancer who have failed one or two prior chemotherapeutic regimens

scientific article published on 02 February 2010

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20127139%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

A Phase II, open-label, randomised study to assess the efficacy and safety of the MEK1/2 inhibitor AZD6244 (ARRY-142886) versus capecitabine monotherapy in patients with colorectal cancer who have failed one or two prior chemotherapeutic regimens (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20127139%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

colorectal cancer

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

colorectal carcinoma

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Jean-Yves Douillard

10

object named as

Jean-Yves Douillard

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20127139%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

author name string

Jaafar Bennouna

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20127139%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Istvan Lang

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20127139%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Manuel Valladares-Ayerbes

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20127139%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Katalin Boer

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20127139%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Antoine Adenis

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20127139%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Pilar Escudero

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20127139%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Tae-You Kim

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20127139%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Gillian M Pover

8

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20127139%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Clive D Morris

9

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20127139%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

publication date

2 February 2010

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20127139%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Investigational New Drugs

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20127139%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

29

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20127139%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20127139%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1021-1028

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20127139%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

https://scigraph.springernature.com/pub.10.1007/s10637-010-9392-8

0 references

Design issues of randomized phase II trials and a proposal for phase II screening trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/20127139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved survival in metastatic colorectal cancer is associated with adoption of hepatic resection and improved chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20127139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in precl

1 reference

https://pubmed.ncbi.nlm.nih.gov/20127139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: results of a large phase III study

1 reference

https://pubmed.ncbi.nlm.nih.gov/20127139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase III Study of Capecitabine Plus Oxaliplatin Compared With Continuous-Infusion Fluorouracil Plus Oxaliplatin As First-Line Therapy in Metastatic Colorectal Cancer: Final Report of the Spanish Cooperative Group for the Treatment of Digestive Tumor

1 reference

https://pubmed.ncbi.nlm.nih.gov/20127139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/20127139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of Raf kinases in malignant transformation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20127139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study

1 reference

https://pubmed.ncbi.nlm.nih.gov/20127139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/20127139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-agent capecitabine in patients with metastatic colorectal cancer refractory to 5-fluorouracil/leucovorin chemotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20127139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Capecitabine as adjuvant treatment for stage III colon cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20127139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical experience of MEK inhibitors in cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20127139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent advances of MEK inhibitors and their clinical progress

1 reference

https://pubmed.ncbi.nlm.nih.gov/20127139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Capecitabine plus oxaliplatin (XELOX) versus 5-fluorouracil/folinic acid plus oxaliplatin (FOLFOX-4) as second-line therapy in metastatic colorectal cancer: a randomized phase III noninferiority study

1 reference

https://pubmed.ncbi.nlm.nih.gov/20127139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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