(Q54315062)

27 May 2018

title

Nutraceutical-mediated restoration of wild-type levels of IKBKAP-encoded IKAP protein in familial dysautonomia-derived cells. (English)

1 reference

27 May 2018

1 reference

2

1 reference

27 May 2018

Austin Peters

6

1 reference

27 May 2018

author name string

Sylvia L Anderson

1

1 reference

27 May 2018

Jinsong Qiu

3

1 reference

27 May 2018

Andrea J Sturm

4

1 reference

27 May 2018

Jamie A Schwartz

5

1 reference

27 May 2018

Kerry A Sullivan

7

1 reference

27 May 2018

Berish Y Rubin

8

1 reference

27 May 2018

publication date

1 April 2012

1 reference

27 May 2018

Molecular Nutrition and Food Research

published in

1 reference

27 May 2018

volume

56

1 reference

27 May 2018

issue

4

1 reference

27 May 2018

page(s)

570-579

1 reference

27 May 2018

The molecular basis of familial dysautonomia: overview, new discoveries and implications for directed therapies

cites work

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Familial dysautonomia is caused by mutations of the IKAP gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

IKAP is a scaffold protein of the IkappaB kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Purification and characterization of the human elongator complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

A novel specific role for I kappa B kinase complex-associated protein in cytosolic stress signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Loss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Elongator function in tRNA wobble uridine modification is conserved between yeast and plants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

IKAP/Elp1 involvement in cytoskeleton regulation and implication for familial dysautonomia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Tocotrienols induce IKBKAP expression: a possible therapy for familial dysautonomia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Tocotrienols reverse IKAP and monoamine oxidase deficiencies in familial dysautonomia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Familial dysautonomia: update and recent advances

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Can the therapeutic efficacy of tocotrienols in neurodegenerative familial dysautonomia patients be measured clinically?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

EGCG corrects aberrant splicing of IKAP mRNA in cells from patients with familial dysautonomia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Rescue of a human mRNA splicing defect by the plant cytokinin kinetin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Phosphatidylserine increases IKBKAP levels in familial dysautonomia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Purification and characterization of a human tumor necrosis factor from the LuKII cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Finding signals that regulate alternative splicing in the post-genomic era

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Regulation of alternative RNA splicing by exon definition and exon sequences in viral and mammalian gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Human Gene Mutation Database (HGMD): 2003 update

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Are splicing mutations the most frequent cause of hereditary disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Kinetin improves IKBKAP mRNA splicing in patients with familial dysautonomia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Use and specificity of genistein as inhibitor of protein-tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Genistein is neuroprotective in murine models of familial amyotrophic lateral sclerosis and stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Neuroprotective effect of genistein against beta amyloid-induced neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

The soy isoflavone, genistein, protects human cortical neuronal cells from oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Genistein ameliorates beta-amyloid peptide (25-35)-induced hippocampal neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Neuroprotective effects of soy phytoestrogens in the rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Soy phytoestrogens are neuroprotective against stroke-like injury in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Cardiovascular effects of the phytoestrogen genistein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Dietary isoflavones in the prevention of cardiovascular disease--a molecular perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Activation of deltaF508 CFTR in a cystic fibrosis respiratory epithelial cell line by 4-phenylbutyrate, genistein and CPX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Prolonged treatment of cells with genistein modulates the expression and function of the cystic fibrosis transmembrane conductance regulator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Regulation of alternative splicing by reversible protein phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Regulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Pharmacokinetics of (-)-epigallocatechin-3-gallate in conscious and freely moving rats and its brain regional distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Concurrent measurement of unbound genistein in the blood, brain and bile of anesthetized rats using microdialysis and its pharmacokinetic application

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Identification and characterization of a spinal muscular atrophy-determining gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Induction of full-length survival motor neuron by polyphenol botanical compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Fludrocortisone in patients with familial dysautonomia--assessing effect on clinical parameters and gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

Elongator, a Multisubunit Component of a Novel RNA Polymerase II Holoenzyme for Transcriptional Elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201100670

21 January 2018

Identifiers

DOI

10.1002/MNFR.201100670

1 reference

27 May 2018

1 reference

27 May 2018