(Q54316067)

27 May 2018

title

Structures and reaction mechanisms of GTP cyclohydrolases. (English)

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27 May 2018

3

Adelbert Bacher

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2

Markus Fischer

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27 May 2018

Tobias Gräwert

series ordinal

1

object named as

Tobias Gräwert

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27 May 2018

publication date

4 March 2013

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27 May 2018

published in

IUBMB Life

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27 May 2018

volume

65

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issue

4

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27 May 2018

page(s)

310-322

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Biosynthesis of flavocoenzymes

cites work

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Zinc plays a key role in human and bacterial GTP cyclohydrolase I

21 January 2018

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GTP cyclohydrolase I utilizes metal-free GTP as its substrate

21 January 2018

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Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I

21 January 2018

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Novel reaction mechanism of GTP cyclohydrolase I. High-resolution X-ray crystallography of Thermus thermophilus HB8 enzyme complexed with a transition state analogue, the 8-oxoguanine derivative

21 January 2018

1 reference

Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP.

21 January 2018

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Structural basis of biopterin-induced inhibition of GTP cyclohydrolase I by GFRP, its feedback regulatory protein

21 January 2018

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Biosynthesis of pteridines. Stopped-flow kinetic analysis of GTP cyclohydrolase I.

21 January 2018

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Ring opening is not rate-limiting in the GTP cyclohydrolase I reaction

21 January 2018

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Reaction mechanism of GTP cyclohydrolase I: single turnover experiments using a kinetically competent reaction intermediate

21 January 2018

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Histidine 179 mutants of GTP cyclohydrolase I catalyze the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone triphosphate.

21 January 2018

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Biosynthesis of tetrahydrofolate. Stereochemistry of dihydroneopterin aldolase

21 January 2018

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Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity

21 January 2018

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GTP cyclohydrolase I feedback regulatory protein is a pentamer of identical subunits. Purification, cDNA cloning, and bacterial expression

21 January 2018

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Decameric GTP cyclohydrolase I forms complexes with two pentameric GTP cyclohydrolase I feedback regulatory proteins in the presence of phenylalanine or of a combination of tetrahydrobiopterin and GTP

21 January 2018

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Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP

21 January 2018

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The N-terminal peptide of mammalian GTP cyclohydrolase I is an autoinhibitory control element and contributes to binding the allosteric regulatory protein GFRP.

21 January 2018

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GTP cyclohydrolase I inhibition by the prototypic inhibitor 2, 4-diamino-6-hydroxypyrimidine. Mechanisms and unanticipated role of GTP cyclohydrolase I feedback regulatory protein

21 January 2018

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The mechanism of potent GTP cyclohydrolase I inhibition by 2,4-diamino-6-hydroxypyrimidine: requirement of the GTP cyclohydrolase I feedback regulatory protein

21 January 2018

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Folate synthesis in plants: the first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase I

21 January 2018

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Discovery of a new prokaryotic type I GTP cyclohydrolase family.

21 January 2018

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Characterization of an Fe(2+)-dependent archaeal-specific GTP cyclohydrolase, MptA, from Methanocaldococcus jannaschii

21 January 2018

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Zinc-Independent Folate Biosynthesis: Genetic, Biochemical, and Structural Investigations Reveal New Metal Dependence for GTP Cyclohydrolase IB

21 January 2018

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An Fe2+-dependent cyclic phosphodiesterase catalyzes the hydrolysis of 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate in methanopterin biosynthesis

21 January 2018

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Biosynthesis of riboflavin: studies on the mechanism of GTP cyclohydrolase II.

21 January 2018

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GTP cyclohydrolase II structure and mechanism

21 January 2018

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Biosynthesis of riboflavin. Single turnover kinetic analysis of GTP cyclohydrolase II.

21 January 2018

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Evolution of new function in the GTP cyclohydrolase II proteins of Streptomyces coelicolor

21 January 2018

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Biosynthesis of vitamin B2.

21 January 2018

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Biosynthesis of riboflavin in plants. The ribA gene of Arabidopsis thaliana specifies a bifunctional GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase

21 January 2018

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Biosynthesis of riboflavin. Screening for an improved GTP cyclohydrolase II mutant

21 January 2018

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A member of a new class of GTP cyclohydrolases produces formylaminopyrimidine nucleotide monophosphates

21 January 2018

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An iron(II) dependent formamide hydrolase catalyzes the second step in the archaeal biosynthetic pathway to riboflavin and 7,8-didemethyl-8-hydroxy-5-deazariboflavin

21 January 2018

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A new use for a familiar fold: the X-ray crystal structure of GTP-bound GTP cyclohydrolase III from Methanocaldococcus jannaschii reveals a two metal ion catalytic mechanism

21 January 2018

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GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence

21 January 2018

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A GTP cyclohydrolase 1 genetic variant delays cancer pain

21 January 2018

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Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients

21 January 2018

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Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IUB.1153

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27 May 2018

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27 May 2018