(Q54340597)

28 May 2018

title

The stereochemical course and mechanism of the IspH reaction. (English)

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28 May 2018

4

Jeroen S Dickschat

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28 May 2018

Christian A Citron

1

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28 May 2018

Nelson L Brock

series ordinal

2

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28 May 2018

Patrick Rabe

series ordinal

3

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28 May 2018

language of work or name

English

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publication date

12 March 2012

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28 May 2018

Angewandte Chemie International Edition

published in

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volume

51

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28 May 2018

issue

17

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28 May 2018

page(s)

4053-4057

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28 May 2018

Sterol molecule: structure, biosynthesis, and function

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Reconstitution of an apicoplast-localised electron transfer pathway involved in the isoprenoid biosynthesis of Plasmodium falciparum

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Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol

21 January 2018

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Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of D-1-deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis.

21 January 2018

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Studies on the nonmevalonate pathway: conversion of 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol to its 2-phospho derivative by 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol kinase

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Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein

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Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein

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Structure of ( E )-4-Hydroxy-3-methyl-but-2-enyl Diphosphate Reductase, the Terminal Enzyme of the Non-Mevalonate Pathway

21 January 2018

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Structure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reduction

21 January 2018

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Isoprenoid biosynthesis via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase (LytB/IspH) from Escherichia coli is a [4Fe-4S] protein.

21 January 2018

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Isoprenoid biosynthesis via the MEP pathway: in vivo Mössbauer spectroscopy identifies a [4Fe-4S]2+ center with unusual coordination sphere in the LytB protein

21 January 2018

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Revisiting the IspH catalytic system in the deoxyxylulose phosphate pathway: achieving high activity.

21 January 2018

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Biosynthesis of isoprene units: Mössbauer spectroscopy of substrate and inhibitor binding to the [4Fe-4S] cluster of the LytB/IspH enzyme

21 January 2018

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Probing the reaction mechanism of IspH protein by x-ray structure analysis

21 January 2018

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Pyridine inhibitor binding to the 4Fe-4S protein A. aeolicus IspH (LytB): a HYSCORE Investigation

21 January 2018

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Inhibition of the Fe(4)S(4)-cluster-containing protein IspH (LytB): electron paramagnetic resonance, metallacycles, and mechanisms

21 January 2018

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The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: studies on the mechanisms of the reactions catalyzed by IspG and IspH protein

21 January 2018

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Mechanistic studies of IspH in the deoxyxylulose phosphate pathway: heterolytic C-O bond cleavage at C4 position

21 January 2018

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IspH protein of the deoxyxylulose phosphate pathway: mechanistic studies with C1-deuterium-labeled substrate and fluorinated analogue

21 January 2018

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Mechanistic studies of an IspH-catalyzed reaction: implications for substrate binding and protonation in the biosynthesis of isoprenoids

21 January 2018

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Bioorganometallic mechanism of action, and inhibition, of IspH

21 January 2018

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LytB protein catalyzes the terminal step of the 2-C-methyl-D-erythritol-4-phosphate pathway of isoprenoid biosynthesis

21 January 2018

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Study of IspH, a key enzyme in the methylerythritol phosphate pathway using fluoro-substituted substrate analogues

21 January 2018

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Stereochemical studies on the making and unmaking of isopentenyl diphosphate in different biological systems.

21 January 2018

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Isoprenoids in three-dimensional space: the stereochemistry of terpene biosynthesis

21 January 2018

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Biosynthesis of terpenoids: 1-deoxy-D-xylulose-5-phosphate reductoisomerase from Escherichia coli is a class B dehydrogenase

21 January 2018

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Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG)

21 January 2018

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An ENDOR and HYSCORE investigation of a reaction intermediate in IspG (GcpE) catalysis

21 January 2018

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Paramagnetic intermediates of (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE/IspG) under steady-state and pre-steady-state conditions

21 January 2018

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IspG-catalyzed positional isotopic exchange in methylerythritol cyclodiphosphate of the deoxyxylulose phosphate pathway: mechanistic implications

21 January 2018

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Deuterium-labelled isotopomers of 2-C-methyl-D-erythritol as tools for the elucidation of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis

21 January 2018

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Evidence for the combined participation of a C10 and a C15 precursor in the biosynthesis of moenocinol, the lipid part of the moenomycin antibiotics

21 January 2018

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Isoprenoid biosynthesis in higher plants and in Escherichia coli: on the branching in the methylerythritol phosphate pathway and the independent biosynthesis of isopentenyl diphosphate and dimethylallyl diphosphate

21 January 2018

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Terpenoid biosynthesis and the stereochemistry of enzyme-catalysed allylic addition—elimination reactions

21 January 2018

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Crystal structures of mutant IspH proteins reveal a rotation of the substrate's hydroxymethyl group during catalysis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ANIE.201201110

1 reference

28 May 2018

1 reference

28 May 2018