(Q54399469)

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The stability of the ternary interferon-receptor complex rather than the affinity to the individual subunits dictates differential biological activities.

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Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/18801736

The stability of the ternary interferon-receptor complex rather than the affinity to the individual subunits dictates differential biological activities. (English)

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Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/18801736

Diego Adhemar Jaitin

2

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Diego A Jaitin

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Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/18801736

author name string

Eyal Kalie

1

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Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/18801736

Yulia Podoplelova

3

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Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/18801736

Jacob Piehler

4

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Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/18801736

Gideon Schreiber

5

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Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/18801736

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publication date

18 September 2008

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Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/18801736

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/18801736

283

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Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/18801736

47

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Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/18801736

32925-32936

1 reference

Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/18801736

The interferon response circuit: induction and suppression by pathogenic viruses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Mechanisms of type-I- and type-II-interferon-mediated signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Type I interferons (alpha/beta) in immunity and autoimmunity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Interferons, interferon-like cytokines, and their receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Review: IFN-alpha/beta receptor interactions to biologic outcomes: understanding the circuitry

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

How cells respond to interferons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Signaling pathways activated by interferons

1 reference

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21 January 2018

Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Differential receptor subunit affinities of type I interferons govern differential signal activation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Identification of residues of the IFNAR1 chain of the type I human interferon receptor critical for ligand binding and biological activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

An interferon alpha2 mutant optimized by phage display for IFNAR1 binding confers specifically enhanced antitumor activities

1 reference

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21 January 2018

Structure of the interferon-receptor complex determined by distance constraints from double-mutant cycles and flexible docking

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Mutational analysis of the IFNAR1 binding site on IFNalpha2 reveals the architecture of a weak ligand-receptor binding-site.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

The Human Type I Interferon Receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

The EM structure of a type I interferon-receptor complex reveals a novel mechanism for cytokine signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Type I interferon receptors: biochemistry and biological functions.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Phage display for selection of novel binding peptides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Ligand-induced assembling of the type I interferon receptor on supported lipid bilayers.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Noncovalent, site-specific biotinylation of histidine-tagged proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Determination of the two-dimensional interaction rate constants of a cytokine receptor complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Lateral ligand-receptor interactions on membranes probed by simultaneous fluorescence-interference detection

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Monitoring the dynamics of ligand-receptor complexes on model membranes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Insulin receptor: covalent labeling and identification of subunits

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Inquiring into the differential action of interferons (IFNs): an IFN-alpha2 mutant with enhanced affinity to IFNAR1 is functionally similar to IFN-beta

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Upregulation of a small subset of genes drives type I interferon-induced antiviral memory

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Normalization of cDNA microarray data

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Identifying differentially expressed genes using false discovery rate controlling procedures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

New structural and functional aspects of the type I interferon-receptor interaction revealed by comprehensive mutational analysis of the binding interface

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Stat-mediated signaling induced by type I and type II interferons (IFNs) is differentially controlled through lipid microdomain association and clathrin-dependent endocytosis of IFN receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Interferon receptor expression regulates the antiproliferative effects of interferons on cancer cells and solid tumors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Growth hormone binding affinity for its receptor surpasses the requirements for cellular activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Comparable potency of IFNalpha2 and IFNbeta on immediate JAK/STAT activation but differential down-regulation of IFNAR2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

The IFNAR1 subunit of the type I IFN receptor complex contains a functional nuclear localization sequence.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Regulated proteolysis of the IFNaR2 subunit of the interferon-alpha receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

TYK2 activity promotes ligand-induced IFNAR1 proteolysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Differential responsiveness to IFN-alpha and IFN-beta of human mature DC through modulation of IFNAR expression.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Interfering with interferon receptor sorting and trafficking: impact on signaling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Ligand-independent pathway that controls stability of interferon alpha receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

The Stat3-activating Tyk2 V678F mutant does not up-regulate signaling through the type I interferon receptor but confers ligand hypersensitivity to a homodimeric receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

IFN-gamma and its receptor subunit IFNGR1 are recruited to the IFN-gamma-activated sequence element at the promoter site of IFN-gamma-activated genes: evidence of transactivational activity in IFNGR1.

1 reference

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21 January 2018

Activation of the Jak-Stat Pathway in Cells That Exhibit Selective Sensitivity to the Antiviral Effects of IFN-beta Compared with IFN-alpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806019200

21 January 2018

Identifiers

10.1074/JBC.M806019200

1 reference

Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/18801736

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/18801736

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