(Q54420633)

29 May 2018

title

Nlrp3 is a key modulator of diet-induced nephropathy and renal cholesterol accumulation. (English)

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29 May 2018

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7

Sandrine Florquin

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29 May 2018

4

Gwendoline J D Teske

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29 May 2018

Jaklien C Leemans

8

object named as

Jaklien C Leemans

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29 May 2018

author name string

Pieter J Bakker

1

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29 May 2018

Loes M Butter

2

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29 May 2018

Lotte Kors

3

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29 May 2018

Jan Aten

5

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29 May 2018

Fayyaz S Sutterwala

6

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29 May 2018

language of work or name

English

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publication date

18 December 2013

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29 May 2018

published in

Kidney International

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29 May 2018

volume

85

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29 May 2018

issue

5

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29 May 2018

page(s)

1112-1122

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29 May 2018

https://scigraph.springernature.com/pub.10.1038/ki.2013.503

exact match

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Fructose, but not dextrose, accelerates the progression of chronic kidney disease.

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Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

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Sensing damage by the NLRP3 inflammasome

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Inflammasome is a central player in the induction of obesity and insulin resistance

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The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

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Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3 inflammasome activation and lipid accumulation

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Allopurinol, quercetin and rutin ameliorate renal NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats

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Cholesterol and phospholipid metabolism in macrophages

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

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A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells.

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7 January 2021

Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis

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7 January 2021

Expression of connective tissue growth factor in human renal fibrosis

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7 January 2021

CTGF promotes inflammatory cell infiltration of the renal interstitium by activating NF-kappaB.

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Sterol regulatory element binding protein 2 activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibility.

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7 January 2021

Gout-associated uric acid crystals activate the NALP3 inflammasome

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7 January 2021

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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7 January 2021

Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome

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7 January 2021

Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling

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7 January 2021

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

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7 January 2021

Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

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7 January 2021

Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity

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7 January 2021

Consuming fructose-sweetened beverages increases body adiposity in mice.

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7 January 2021

Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury

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7 January 2021

Chemokine expression in renal ischemia/reperfusion injury is most profound during the reparative phase

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7 January 2021

Identifiers

DOI

10.1038/KI.2013.503

1 reference

29 May 2018

PubMed ID

24352154

1 reference

29 May 2018