(Q54440212)

29 May 2018

title

Pilicides-small molecules targeting bacterial virulence. (English)

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29 May 2018

Fredrik Almqvist

2

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author name string

Veronica Aberg

series ordinal

1

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29 May 2018

publication date

20 April 2007

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29 May 2018

Organic and Biomolecular Chemistry

published in

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29 May 2018

volume

5

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issue

12

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page(s)

1827-1834

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29 May 2018

Targeting virulence for antibacterial chemotherapy: identifying and characterising virulence factors for lead discovery

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21 January 2018

1 reference

Structural basis of chaperone function and pilus biogenesis

21 January 2018

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PapD, a periplasmic transport protein in P-pilus biogenesis

21 January 2018

1 reference

FimC, a chaperone-like periplasmic protein of Escherichia coli involved in biogenesis of type 1 fimbriae

21 January 2018

1 reference

Structural basis of pilus subunit recognition by the PapD chaperone.

21 January 2018

1 reference

Bacterial outer membrane ushers contain distinct targeting and assembly domains for pilus biogenesis

21 January 2018

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The usher N terminus is the initial targeting site for chaperone-subunit complexes and participates in subsequent pilus biogenesis events

21 January 2018

1 reference

Structural basis of chaperone-subunit complex recognition by the type 1 pilus assembly platform FimD.

21 January 2018

1 reference

P pili in uropathogenic E. coli are composite fibres with distinct fibrillar adhesive tips

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Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor

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The distinct binding specificities exhibited by enterobacterial type 1 fimbriae are determined by their fimbrial shafts

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Physical properties of Escherichia coli P pili measured by optical tweezers

21 January 2018

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The unfolding of the P pili quaternary structure by stretching is reversible, not plastic.

21 January 2018

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Uncoiling mechanics of Escherichia coli type I fimbriae are optimized for catch bonds

21 January 2018

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The mechanical properties of E. coli type 1 pili measured by atomic force microscopy techniques

21 January 2018

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Bacterial adhesion to target cells enhanced by shear force

21 January 2018

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Crystal structure of chaperone protein PapD reveals an immunoglobulin fold

21 January 2018

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FimC is a periplasmic PapD-like chaperone that directs assembly of type 1 pili in bacteria

21 January 2018

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NMR solution structure of the periplasmic chaperone FimC

21 January 2018

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Periplasmic chaperone recognition motif of subunits mediates quaternary interactions in the pilus

21 January 2018

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X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli

21 January 2018

1 reference

An enantioselective ketene-imine cycloaddition method for synthesis of substituted ring-fused 2-pyridinones

21 January 2018

1 reference

Efficient microwave assisted synthesis of optically active bicyclic 2-pyridinones via delta2-thiazolines

21 January 2018

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Design and parallel solid-phase synthesis of ring-fused 2-pyridinones that target pilus biogenesis in pathogenic bacteria

21 January 2018

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Microwave-assisted decarboxylation of bicyclic 2-pyridone scaffolds and identification of Abeta-peptide aggregation inhibitors

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Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.

21 January 2018

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Microwave-assisted synthesis of highly substituted aminomethylated 2-pyridones

21 January 2018

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Design, synthesis, and application of azabicyclo[X.Y.0]alkanone amino acids as constrained dipeptide surrogates and peptide mimics

21 January 2018

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Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 8. Pharmacological optimization of orally bioavailable 2-pyridone-containing peptidomimetics.

21 January 2018

1 reference

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. Part 7: structure-activity studies of bicyclic 2-pyridone-containing peptidomimetics

21 January 2018

1 reference

C-Terminal properties are important for ring-fused 2-pyridones that interfere with the chaperone function in uropathogenic E. coli.

21 January 2018

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NMR studies of interactions between periplasmic chaperones from uropathogenic E. coli and pilicides that interfere with chaperone function and pilus assembly.

21 January 2018

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Pilicides regulate pili expression in E. coli without affecting the functional properties of the pilus rod.

21 January 2018

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Drugs for bad bugs: confronting the challenges of antibacterial discovery

21 January 2018

1 reference

21 January 2018

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Implication of biofilm formation in the persistence of urinary tract infection caused by uropathogenic Escherichia coli

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1039/B702397A

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29 May 2018

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29 May 2018